Epigenetic mechanisms governing the process of neurodegeneration

Irfan A. Qureshi; Mark F. Mehler

doi:10.1016/j.mam.2012.06.011

Epigenetic mechanisms governing the process of neurodegeneration

Irfan A. Qureshi, Mark F. Mehler

Neurology

Research output: Contribution to journal › Review article › peer-review

31 Scopus citations

Abstract

Studies elucidating how and why neurodegeneration unfolds suggest that a complex interplay between genetic and environmental factors is responsible for disease pathogenesis. Recent breakthroughs in the field of epigenetics promise to advance our understanding of these mechanisms and to promote the development of useful and effective pre-clinical risk stratification strategies, molecular diagnostic and prognostic methods, and disease-modifying treatments.

Original language	English (US)
Pages (from-to)	875-882
Number of pages	8
Journal	Molecular aspects of medicine
Volume	34
Issue number	4
DOIs	https://doi.org/10.1016/j.mam.2012.06.011
State	Published - Jul 2013

Keywords

Chromatin
Epigenetic
Histone deacetylase
Histone modification
Neurodegenerative disease
Non-coding RNA

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Clinical Biochemistry

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10.1016/j.mam.2012.06.011

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title = "Epigenetic mechanisms governing the process of neurodegeneration",

abstract = "Studies elucidating how and why neurodegeneration unfolds suggest that a complex interplay between genetic and environmental factors is responsible for disease pathogenesis. Recent breakthroughs in the field of epigenetics promise to advance our understanding of these mechanisms and to promote the development of useful and effective pre-clinical risk stratification strategies, molecular diagnostic and prognostic methods, and disease-modifying treatments.",

keywords = "Chromatin, Epigenetic, Histone deacetylase, Histone modification, Neurodegenerative disease, Non-coding RNA",

author = "Qureshi, {Irfan A.} and Mehler, {Mark F.}",

note = "Funding Information: We regret that space constraints have prevented the citation of many relevant and important references. M.F.M. is supported by grants from the National Institutes of Health (NS071571, HD071593, MH66290), as well as by the F.M. Kirby, Alpern Family, Mildred and Bernard H. Kayden and Roslyn and Leslie Goldstein Foundations. ",

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AU - Mehler, Mark F.

N1 - Funding Information: We regret that space constraints have prevented the citation of many relevant and important references. M.F.M. is supported by grants from the National Institutes of Health (NS071571, HD071593, MH66290), as well as by the F.M. Kirby, Alpern Family, Mildred and Bernard H. Kayden and Roslyn and Leslie Goldstein Foundations.

PY - 2013/7

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AB - Studies elucidating how and why neurodegeneration unfolds suggest that a complex interplay between genetic and environmental factors is responsible for disease pathogenesis. Recent breakthroughs in the field of epigenetics promise to advance our understanding of these mechanisms and to promote the development of useful and effective pre-clinical risk stratification strategies, molecular diagnostic and prognostic methods, and disease-modifying treatments.

KW - Chromatin

KW - Epigenetic

KW - Histone deacetylase

KW - Histone modification

KW - Neurodegenerative disease

KW - Non-coding RNA

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JF - Molecular aspects of medicine

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Epigenetic mechanisms governing the process of neurodegeneration

Abstract

Keywords

ASJC Scopus subject areas

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