Epigenetic mechanisms governing the process of neurodegeneration

Irfan A. Qureshi, Mark F. Mehler

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

Studies elucidating how and why neurodegeneration unfolds suggest that a complex interplay between genetic and environmental factors is responsible for disease pathogenesis. Recent breakthroughs in the field of epigenetics promise to advance our understanding of these mechanisms and to promote the development of useful and effective pre-clinical risk stratification strategies, molecular diagnostic and prognostic methods, and disease-modifying treatments.

Original languageEnglish (US)
Pages (from-to)875-882
Number of pages8
JournalMolecular aspects of medicine
Volume34
Issue number4
DOIs
StatePublished - Jul 1 2013

Keywords

  • Chromatin
  • Epigenetic
  • Histone deacetylase
  • Histone modification
  • Neurodegenerative disease
  • Non-coding RNA

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry

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