Epigenetic factors in aging and longevity

Silvia Gravina, Jan Vijg

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Epigenetics refers to phenotypic changes caused by mechanisms that are unrelated to changes in the underlying DNA sequence, most notably chromatin remodeling driven by histone modifications, and DNA methylation. Such variation is transmitted by cell division, but generally not passed on through the germ line. An increasing body of evidence supports a role for epigenetic changes in the etiology of aging and its associated disease sequelae. Here, we review the role of epigenetics in aging and longevity with a focus on DNA methylation. Increased understanding of those aging-related processes that are driven by epigenetic mechanisms will allow for the development of novel epigenetic-based diagnostic, preventive, and therapeutic strategies for age-related diseases.

Original languageEnglish (US)
Pages (from-to)247-258
Number of pages12
JournalPflugers Archiv European Journal of Physiology
Volume459
Issue number2
DOIs
StatePublished - Jan 2010

Fingerprint

Epigenomics
Aging of materials
DNA Methylation
Histone Code
DNA sequences
Genetic Epigenesis
Histones
Chromatin
Chromatin Assembly and Disassembly
Cells
Germ Cells
Cell Division
Therapeutics

Keywords

  • Aging
  • DNA methylation
  • Epigenetics
  • Lifespan

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

Cite this

Epigenetic factors in aging and longevity. / Gravina, Silvia; Vijg, Jan.

In: Pflugers Archiv European Journal of Physiology, Vol. 459, No. 2, 01.2010, p. 247-258.

Research output: Contribution to journalArticle

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