Epigenetic factors in aging and longevity

Silvia Gravina; Jan Vijg

doi:10.1007/s00424-009-0730-7

Epigenetic factors in aging and longevity

Silvia Gravina, Jan Vijg

Genetics

Research output: Contribution to journal › Review article › peer-review

113 Scopus citations

Abstract

Epigenetics refers to phenotypic changes caused by mechanisms that are unrelated to changes in the underlying DNA sequence, most notably chromatin remodeling driven by histone modifications, and DNA methylation. Such variation is transmitted by cell division, but generally not passed on through the germ line. An increasing body of evidence supports a role for epigenetic changes in the etiology of aging and its associated disease sequelae. Here, we review the role of epigenetics in aging and longevity with a focus on DNA methylation. Increased understanding of those aging-related processes that are driven by epigenetic mechanisms will allow for the development of novel epigenetic-based diagnostic, preventive, and therapeutic strategies for age-related diseases.

Original language	English (US)
Pages (from-to)	247-258
Number of pages	12
Journal	Pflugers Archiv European Journal of Physiology
Volume	459
Issue number	2
DOIs	https://doi.org/10.1007/s00424-009-0730-7
State	Published - Jan 2010

Keywords

Aging
DNA methylation
Epigenetics
Lifespan

ASJC Scopus subject areas

Physiology
Clinical Biochemistry
Physiology (medical)

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10.1007/s00424-009-0730-7

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AU - Vijg, Jan

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AB - Epigenetics refers to phenotypic changes caused by mechanisms that are unrelated to changes in the underlying DNA sequence, most notably chromatin remodeling driven by histone modifications, and DNA methylation. Such variation is transmitted by cell division, but generally not passed on through the germ line. An increasing body of evidence supports a role for epigenetic changes in the etiology of aging and its associated disease sequelae. Here, we review the role of epigenetics in aging and longevity with a focus on DNA methylation. Increased understanding of those aging-related processes that are driven by epigenetic mechanisms will allow for the development of novel epigenetic-based diagnostic, preventive, and therapeutic strategies for age-related diseases.

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KW - Lifespan

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Epigenetic factors in aging and longevity

Abstract

Keywords

ASJC Scopus subject areas

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