Epigenetic factors in aging and longevity

Silvia Gravina, Jan Vijg

Research output: Contribution to journalReview article

97 Scopus citations

Abstract

Epigenetics refers to phenotypic changes caused by mechanisms that are unrelated to changes in the underlying DNA sequence, most notably chromatin remodeling driven by histone modifications, and DNA methylation. Such variation is transmitted by cell division, but generally not passed on through the germ line. An increasing body of evidence supports a role for epigenetic changes in the etiology of aging and its associated disease sequelae. Here, we review the role of epigenetics in aging and longevity with a focus on DNA methylation. Increased understanding of those aging-related processes that are driven by epigenetic mechanisms will allow for the development of novel epigenetic-based diagnostic, preventive, and therapeutic strategies for age-related diseases.

Original languageEnglish (US)
Pages (from-to)247-258
Number of pages12
JournalPflugers Archiv European Journal of Physiology
Volume459
Issue number2
DOIs
StatePublished - Jan 1 2010

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Keywords

  • Aging
  • DNA methylation
  • Epigenetics
  • Lifespan

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

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