Epigenetic dysregulation by aberrant metabolism in renal cell carcinoma can be reversed with Ascorbic acid

Niraj Shenoy

doi:10.1080/23723556.2019.1595309

Epigenetic dysregulation by aberrant metabolism in renal cell carcinoma can be reversed with Ascorbic acid

Niraj Shenoy

Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Our recently published study uncovered mechanisms and prognostic impact of aberrant DNA methylation/hydroxymethylation in clear cell renal cell carcinoma, and comprehensively explored the potential of Ascorbic acid in reversing the epigenetic aberrancy. This article provides a summary of the findings and their translational significance, and important considerations while testing Ascorbic acid as an anti-cancer agent. Abbreviations-ccRCC: clear cell renal cell carcinoma; TET: Ten-Eleven Translocation; 5mC: 5-methylcytosine; 5hmC: 5-hydroxymethylcytosine; L2HG: l-2-hydroxyglutarate; L2HGDH: l-2-hydroxyglutarate dehydrogenase; 2-OG: 2-Oxoglutarate; AA: Ascorbic acid.

Original language	English (US)
Article number	1595309
Journal	Molecular and Cellular Oncology
Volume	6
Issue number	3
DOIs	https://doi.org/10.1080/23723556.2019.1595309
State	Published - May 4 2019

Keywords

Ascorbic acid
cancer
epigenetics
hydroxymethylcytosine
kidney cancer

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/23723556.2019.1595309

Cite this

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title = "Epigenetic dysregulation by aberrant metabolism in renal cell carcinoma can be reversed with Ascorbic acid",

abstract = "Our recently published study uncovered mechanisms and prognostic impact of aberrant DNA methylation/hydroxymethylation in clear cell renal cell carcinoma, and comprehensively explored the potential of Ascorbic acid in reversing the epigenetic aberrancy. This article provides a summary of the findings and their translational significance, and important considerations while testing Ascorbic acid as an anti-cancer agent. Abbreviations-ccRCC: clear cell renal cell carcinoma; TET: Ten-Eleven Translocation; 5mC: 5-methylcytosine; 5hmC: 5-hydroxymethylcytosine; L2HG: l-2-hydroxyglutarate; L2HGDH: l-2-hydroxyglutarate dehydrogenase; 2-OG: 2-Oxoglutarate; AA: Ascorbic acid.",

keywords = "Ascorbic acid, cancer, epigenetics, hydroxymethylcytosine, kidney cancer",

author = "Niraj Shenoy",

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year = "2019",

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doi = "10.1080/23723556.2019.1595309",

language = "English (US)",

volume = "6",

journal = "Molecular and Cellular Oncology",

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AU - Shenoy, Niraj

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AB - Our recently published study uncovered mechanisms and prognostic impact of aberrant DNA methylation/hydroxymethylation in clear cell renal cell carcinoma, and comprehensively explored the potential of Ascorbic acid in reversing the epigenetic aberrancy. This article provides a summary of the findings and their translational significance, and important considerations while testing Ascorbic acid as an anti-cancer agent. Abbreviations-ccRCC: clear cell renal cell carcinoma; TET: Ten-Eleven Translocation; 5mC: 5-methylcytosine; 5hmC: 5-hydroxymethylcytosine; L2HG: l-2-hydroxyglutarate; L2HGDH: l-2-hydroxyglutarate dehydrogenase; 2-OG: 2-Oxoglutarate; AA: Ascorbic acid.

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KW - kidney cancer

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Epigenetic dysregulation by aberrant metabolism in renal cell carcinoma can be reversed with Ascorbic acid

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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