Epigenetic dysregulation by aberrant metabolism in renal cell carcinoma can be reversed with Ascorbic acid

Abstract

Our recently published study uncovered mechanisms and prognostic impact of aberrant DNA methylation/hydroxymethylation in clear cell renal cell carcinoma, and comprehensively explored the potential of Ascorbic acid in reversing the epigenetic aberrancy. This article provides a summary of the findings and their translational significance, and important considerations while testing Ascorbic acid as an anti-cancer agent. Abbreviations-ccRCC: clear cell renal cell carcinoma; TET: Ten-Eleven Translocation; 5mC: 5-methylcytosine; 5hmC: 5-hydroxymethylcytosine; L2HG: l-2-hydroxyglutarate; L2HGDH: l-2-hydroxyglutarate dehydrogenase; 2-OG: 2-Oxoglutarate; AA: Ascorbic acid.

Original languageEnglish (US)
Article number1595309
JournalMolecular and Cellular Oncology
Volume6
Issue number3
DOIs
Publication statusPublished - May 4 2019

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Keywords

  • Ascorbic acid
  • cancer
  • epigenetics
  • hydroxymethylcytosine
  • kidney cancer

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

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