Epigenetic and Genetic Factors that Regulate Gene Expression in Toxoplasma gondii

William J. Sullivan, Joshua B. Radke, Kami Kim, Michael W. White

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

As it passes through its life-cycle and different hosts, Toxoplasma gondii must sense and respond to changes in its environment. T. gondii life cycle transitions and cell cycle changes are accompanied by major changes in gene expression and the parasite transcriptome. While many of the components of the general transcription machinery are conserved, few classic transcription factors were identified until the ApiAP2 APETELA plant-like transcription family was discovered. Gene expression, including bradyzoite differentiation, is also controlled by epigenetic factors. This chapter reviews current efforts to understand the role of ApiAP2 in transcriptional regulation and the importance of epigenetic factors and post-transcriptional mechanisms of gene regulation in Toxoplasma.

Original languageEnglish (US)
Title of host publicationToxoplasma Gondii: The Model Apicomplexan - Perspectives and Methods: Second Edition
PublisherElsevier Ltd.
Pages613-645
Number of pages33
ISBN (Print)9780123964816
DOIs
StatePublished - Sep 2013

Fingerprint

Toxoplasma
Epigenomics
Life Cycle Stages
Gene Expression
Transcriptome
Cell Cycle
Parasites
Transcription Factors
Genes

Keywords

  • APETELA (AP2)
  • Chromatin remodeling
  • Epigenetics
  • Histone modification
  • Transcription
  • Transcription factor
  • Translational regulation

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

Sullivan, W. J., Radke, J. B., Kim, K., & White, M. W. (2013). Epigenetic and Genetic Factors that Regulate Gene Expression in Toxoplasma gondii. In Toxoplasma Gondii: The Model Apicomplexan - Perspectives and Methods: Second Edition (pp. 613-645). Elsevier Ltd.. https://doi.org/10.1016/B978-0-12-396481-6.00018-0

Epigenetic and Genetic Factors that Regulate Gene Expression in Toxoplasma gondii. / Sullivan, William J.; Radke, Joshua B.; Kim, Kami; White, Michael W.

Toxoplasma Gondii: The Model Apicomplexan - Perspectives and Methods: Second Edition. Elsevier Ltd., 2013. p. 613-645.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sullivan, WJ, Radke, JB, Kim, K & White, MW 2013, Epigenetic and Genetic Factors that Regulate Gene Expression in Toxoplasma gondii. in Toxoplasma Gondii: The Model Apicomplexan - Perspectives and Methods: Second Edition. Elsevier Ltd., pp. 613-645. https://doi.org/10.1016/B978-0-12-396481-6.00018-0
Sullivan WJ, Radke JB, Kim K, White MW. Epigenetic and Genetic Factors that Regulate Gene Expression in Toxoplasma gondii. In Toxoplasma Gondii: The Model Apicomplexan - Perspectives and Methods: Second Edition. Elsevier Ltd. 2013. p. 613-645 https://doi.org/10.1016/B978-0-12-396481-6.00018-0
Sullivan, William J. ; Radke, Joshua B. ; Kim, Kami ; White, Michael W. / Epigenetic and Genetic Factors that Regulate Gene Expression in Toxoplasma gondii. Toxoplasma Gondii: The Model Apicomplexan - Perspectives and Methods: Second Edition. Elsevier Ltd., 2013. pp. 613-645
@inbook{c5513048c15841479728bb5992fb6926,
title = "Epigenetic and Genetic Factors that Regulate Gene Expression in Toxoplasma gondii",
abstract = "As it passes through its life-cycle and different hosts, Toxoplasma gondii must sense and respond to changes in its environment. T. gondii life cycle transitions and cell cycle changes are accompanied by major changes in gene expression and the parasite transcriptome. While many of the components of the general transcription machinery are conserved, few classic transcription factors were identified until the ApiAP2 APETELA plant-like transcription family was discovered. Gene expression, including bradyzoite differentiation, is also controlled by epigenetic factors. This chapter reviews current efforts to understand the role of ApiAP2 in transcriptional regulation and the importance of epigenetic factors and post-transcriptional mechanisms of gene regulation in Toxoplasma.",
keywords = "APETELA (AP2), Chromatin remodeling, Epigenetics, Histone modification, Transcription, Transcription factor, Translational regulation",
author = "Sullivan, {William J.} and Radke, {Joshua B.} and Kami Kim and White, {Michael W.}",
year = "2013",
month = "9",
doi = "10.1016/B978-0-12-396481-6.00018-0",
language = "English (US)",
isbn = "9780123964816",
pages = "613--645",
booktitle = "Toxoplasma Gondii: The Model Apicomplexan - Perspectives and Methods: Second Edition",
publisher = "Elsevier Ltd.",

}

TY - CHAP

T1 - Epigenetic and Genetic Factors that Regulate Gene Expression in Toxoplasma gondii

AU - Sullivan, William J.

AU - Radke, Joshua B.

AU - Kim, Kami

AU - White, Michael W.

PY - 2013/9

Y1 - 2013/9

N2 - As it passes through its life-cycle and different hosts, Toxoplasma gondii must sense and respond to changes in its environment. T. gondii life cycle transitions and cell cycle changes are accompanied by major changes in gene expression and the parasite transcriptome. While many of the components of the general transcription machinery are conserved, few classic transcription factors were identified until the ApiAP2 APETELA plant-like transcription family was discovered. Gene expression, including bradyzoite differentiation, is also controlled by epigenetic factors. This chapter reviews current efforts to understand the role of ApiAP2 in transcriptional regulation and the importance of epigenetic factors and post-transcriptional mechanisms of gene regulation in Toxoplasma.

AB - As it passes through its life-cycle and different hosts, Toxoplasma gondii must sense and respond to changes in its environment. T. gondii life cycle transitions and cell cycle changes are accompanied by major changes in gene expression and the parasite transcriptome. While many of the components of the general transcription machinery are conserved, few classic transcription factors were identified until the ApiAP2 APETELA plant-like transcription family was discovered. Gene expression, including bradyzoite differentiation, is also controlled by epigenetic factors. This chapter reviews current efforts to understand the role of ApiAP2 in transcriptional regulation and the importance of epigenetic factors and post-transcriptional mechanisms of gene regulation in Toxoplasma.

KW - APETELA (AP2)

KW - Chromatin remodeling

KW - Epigenetics

KW - Histone modification

KW - Transcription

KW - Transcription factor

KW - Translational regulation

UR - http://www.scopus.com/inward/record.url?scp=84904087274&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904087274&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-396481-6.00018-0

DO - 10.1016/B978-0-12-396481-6.00018-0

M3 - Chapter

SN - 9780123964816

SP - 613

EP - 645

BT - Toxoplasma Gondii: The Model Apicomplexan - Perspectives and Methods: Second Edition

PB - Elsevier Ltd.

ER -