Epidemiology of acquisition and clearance of cervical human papillomavirus infection in women from a high-risk area for cervical cancer

Eduardo L. Franco, Luisa L. Villa, Joao P. Sobrinho, José M. Prado, Marie Claude Rousseau, Marie Désy, Thomas E. Rohan

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Acquisition and clearance of cervical human papillomavirus (HPV) infection were analyzed among 1425 low-income women attending a maternal and child health program in Sao Paulo, Brazil. Specimens collected every 4 months were tested by a polymerase chain reaction protocol (MY09/11). In all, 357 subjects were positive at least once. There were 1.3% new infections per month, with 38% cumulative positivity after 18 months. Of 177 positive subjects at enrollment, only 35% remained infected after 12 months. The monthly clearance rate was higher for nononcogenic types (12.2%; 95% confidence interval [CI], 9.6-15.4) than for oncogenic HPV infections (9.5%; 95% CI, 7.5-11.9). Median retention times were 8.1 months (95% CI, 7.8-8.3) for oncogenic types and 4.8 months (95% CI, 3.9-5,6) for nononcogenic HPV infections. The mean infection durations were 8.2 and 13.5 months for nononcogenic and oncogenic types, respectively. Although a woman's age did not affect mean duration for oncogenic types (13-14 months), nononcogenic- type infections lasted longer (10.2 months) among younger (<35 years old) than in older women (5.6 months).

Original languageEnglish (US)
Pages (from-to)1415-1423
Number of pages9
JournalJournal of Infectious Diseases
Issue number5
StatePublished - Nov 9 1999


ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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