TY - JOUR
T1 - Epidemiology of acquisition and clearance of cervical human papillomavirus infection in women from a high-risk area for cervical cancer
AU - Franco, Eduardo L.
AU - Villa, Luisa L.
AU - Sobrinho, Joao P.
AU - Prado, José M.
AU - Rousseau, Marie Claude
AU - Désy, Marie
AU - Rohan, Thomas E.
N1 - Funding Information:
Grant support: NIH (CA-70269); Medical Research Council of Canada (MA-13647).
PY - 1999
Y1 - 1999
N2 - Acquisition and clearance of cervical human papillomavirus (HPV) infection were analyzed among 1425 low-income women attending a maternal and child health program in Sao Paulo, Brazil. Specimens collected every 4 months were tested by a polymerase chain reaction protocol (MY09/11). In all, 357 subjects were positive at least once. There were 1.3% new infections per month, with 38% cumulative positivity after 18 months. Of 177 positive subjects at enrollment, only 35% remained infected after 12 months. The monthly clearance rate was higher for nononcogenic types (12.2%; 95% confidence interval [CI], 9.6-15.4) than for oncogenic HPV infections (9.5%; 95% CI, 7.5-11.9). Median retention times were 8.1 months (95% CI, 7.8-8.3) for oncogenic types and 4.8 months (95% CI, 3.9-5,6) for nononcogenic HPV infections. The mean infection durations were 8.2 and 13.5 months for nononcogenic and oncogenic types, respectively. Although a woman's age did not affect mean duration for oncogenic types (13-14 months), nononcogenic- type infections lasted longer (10.2 months) among younger (<35 years old) than in older women (5.6 months).
AB - Acquisition and clearance of cervical human papillomavirus (HPV) infection were analyzed among 1425 low-income women attending a maternal and child health program in Sao Paulo, Brazil. Specimens collected every 4 months were tested by a polymerase chain reaction protocol (MY09/11). In all, 357 subjects were positive at least once. There were 1.3% new infections per month, with 38% cumulative positivity after 18 months. Of 177 positive subjects at enrollment, only 35% remained infected after 12 months. The monthly clearance rate was higher for nononcogenic types (12.2%; 95% confidence interval [CI], 9.6-15.4) than for oncogenic HPV infections (9.5%; 95% CI, 7.5-11.9). Median retention times were 8.1 months (95% CI, 7.8-8.3) for oncogenic types and 4.8 months (95% CI, 3.9-5,6) for nononcogenic HPV infections. The mean infection durations were 8.2 and 13.5 months for nononcogenic and oncogenic types, respectively. Although a woman's age did not affect mean duration for oncogenic types (13-14 months), nononcogenic- type infections lasted longer (10.2 months) among younger (<35 years old) than in older women (5.6 months).
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U2 - 10.1086/315086
DO - 10.1086/315086
M3 - Article
C2 - 10515798
AN - SCOPUS:0032730126
SN - 0022-1899
VL - 180
SP - 1415
EP - 1423
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 5
ER -