Epidemiologic study of myelodysplastic syndromes in a multiethnic, inner city cohort

Ashwin Sridharan, Rishi Jain, Marcus A. Bachhuber, Yiting Yu, KH H. Ramesh, Krishna Gundabolu, Ellen W. Friedman, Amit K. Verma

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Little is known about the epidemiology of MDS in minority populations. The IPSS and newly released IPSS-R are important clinical tools in prognostication of patients with MDS. Therefore, we conducted a retrospective epidemiological analysis of MDS in an ethnically diverse cohort of patients. Demographics, disease characteristics, and survival were determined in 161 patients seen at Montefiore Medical Center from 1997 to 2011. We observed that Hispanics presented at a younger age than blacks and whites (68 vs. 73.7 vs. 75.6 years); this difference was significant (p = 0.01). A trend towards greater prevalence of thrombocytopenia in Hispanics was observed, but this was not significant (p = 0.08). No other differences between the groups were observed. Overall median survival after diagnosis was the highest among Hispanics (8.6 years) followed by blacks (6.2 years) and Caucasians (3.7). Adjusted hazard ratios however did not show significant differences in risk of death between the groups. The IPSS-R showed slightly better discrimination when compared to the IPSS in this cohort (Somers Dxy 0.39 vs. 0.35, respectively) but observed survival more was more closely approximated by IPSS than by IPSS-R. Our study highlights the possibility of ethnic differences in the presentation of MDS and raises questions regarding which prognostic system is more predictive in this population.

Original languageEnglish (US)
Article number22
Pages (from-to)1-6
Number of pages6
JournalExperimental Hematology and Oncology
Volume3
Issue number1
DOIs
StatePublished - Aug 23 2014

Keywords

  • Ethnicity
  • IPSS
  • IPSS-R
  • Myelodysplastic syndrome
  • Prognosis

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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