TY - JOUR
T1 - Epidemiologic and clinical characteristics of infective endocarditis
T2 - a single-center retrospective study in the Bronx, New York
AU - Liaqat, Wasla
AU - Palaiodimos, Leonidas
AU - Li, Weijia
AU - Karamanis, Dimitrios
AU - Tahir, Arooj
AU - Tzoumas, Andreas
AU - Nagraj, Sanjana
AU - Tiwari, Nidhish
AU - Grushko, Michael
AU - Kokkinidis, Damianos
AU - Gashi, Eleonora
AU - Leider, Jason
AU - Coyle, Christina
AU - Faillace, Robert T.
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
PY - 2022/10
Y1 - 2022/10
N2 - Objective: There is paucity of data on the epidemiological, microbiological, and clinical characteristics of patients admitted with infective endocarditis (IE) in the Bronx, New York. Patient and methods: We conducted a retrospective study at Jacobi Medical Center, a tertiary care hospital in the Bronx. All adult patients who were hospitalized with a primary diagnosis of new-onset IE between January 1st, 2010 and September 30th, 2020 were included. The primary outcome was in-hospital mortality. A logistic regression model was used to identify baseline variables associated with in-hospital mortality. Results: 182 patients were included in this analysis (female sex: 38.5%, median age: 54 years). 46 patients (25.3%) reported intravenous drug use. 153 patients (84.1%) had positive blood cultures. Staphylococcusaureus (S.aureus) was the most common isolated pathogen (45.1% of monomicrobial IE). Nearly half of the cases secondary to S.aureus were methicillin resistant Staphylococcusaureus (MRSA) (34/69). 164 patients (90.1%) were diagnosed with native valve IE. The mitral valve was involved in 32.4% of patients followed by the aortic valve (19.8%). The in-hospital mortality was 18.1%. The mortality was higher in the cohort 2010–2015 compared to the cohort 2016–2020 (22.1% vs 14.6%). Increasing age, MRSA IE, and active malignancy were the only variables found to have significant association with in-hospital death. Conclusion: S.aureus was the most common causative agent and MRSA accounted for about half of the S.aureus IE cases. The incidence of IE in patients with intravenous drug use increased over time, while the median age decreased. The in-hospital death rate was higher in 2010–2015 compared to 2016–2020.
AB - Objective: There is paucity of data on the epidemiological, microbiological, and clinical characteristics of patients admitted with infective endocarditis (IE) in the Bronx, New York. Patient and methods: We conducted a retrospective study at Jacobi Medical Center, a tertiary care hospital in the Bronx. All adult patients who were hospitalized with a primary diagnosis of new-onset IE between January 1st, 2010 and September 30th, 2020 were included. The primary outcome was in-hospital mortality. A logistic regression model was used to identify baseline variables associated with in-hospital mortality. Results: 182 patients were included in this analysis (female sex: 38.5%, median age: 54 years). 46 patients (25.3%) reported intravenous drug use. 153 patients (84.1%) had positive blood cultures. Staphylococcusaureus (S.aureus) was the most common isolated pathogen (45.1% of monomicrobial IE). Nearly half of the cases secondary to S.aureus were methicillin resistant Staphylococcusaureus (MRSA) (34/69). 164 patients (90.1%) were diagnosed with native valve IE. The mitral valve was involved in 32.4% of patients followed by the aortic valve (19.8%). The in-hospital mortality was 18.1%. The mortality was higher in the cohort 2010–2015 compared to the cohort 2016–2020 (22.1% vs 14.6%). Increasing age, MRSA IE, and active malignancy were the only variables found to have significant association with in-hospital death. Conclusion: S.aureus was the most common causative agent and MRSA accounted for about half of the S.aureus IE cases. The incidence of IE in patients with intravenous drug use increased over time, while the median age decreased. The in-hospital death rate was higher in 2010–2015 compared to 2016–2020.
KW - Bronx
KW - Epidemiology
KW - Infective endocarditis
KW - New York
KW - Observational study
KW - Staphylococcusaureus
UR - http://www.scopus.com/inward/record.url?scp=85130750329&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85130750329&partnerID=8YFLogxK
U2 - 10.1007/s15010-022-01846-3
DO - 10.1007/s15010-022-01846-3
M3 - Article
C2 - 35614176
AN - SCOPUS:85130750329
SN - 0300-8126
VL - 50
SP - 1349
EP - 1361
JO - Infection
JF - Infection
IS - 5
ER -