Epicardial fat volume in patients with left ventricular systolic dysfunction

Tuba Khawaja, Christine Greer, Aalap Chokshi, Nelson Chavarria, Samir Thadani, Meaghan Jones, Kenneth Schaefle, Ketan Bhatia, J. Elias Collado, Daichi Shimbo, Andrew J. Einstein, P. Christian Schulze

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Epicardial adipose tissue has been linked to cardiovascular metabolism and inflammation and has been shown to predict prevalence and progression of coronary artery disease. Only limited data are available on the role of epicardial fat in patients with heart failure (HF). We analyzed cardiac adiposity and its relation to markers of morbidity and clinical outcome in patients with normal and impaired left ventricular (LV) function. Epicardial fat volume (EFV) and coronary artery calcium were measured in 381 patients (210 women and 171 men, mean age 55 ± 10 years) who underwent low-dose computed tomography. HF was defined by LV ejection fraction (EF) <55%. Three hundred twenty-one patients had an EF >55% (mean 63 ± 6) and 60 patients had an EF <55% (mean 41 ± 12). Subgroup analysis was performed according to degree of LV dysfunction in patients with HF (LVEF 35% to 55% or <35%). Mean EFVs were 114.5 ± 98.5 cm3 in patients with normal EF and 83.5 ± 67.1 cm3 in those with decreased EF (p <0.05). Mean EFVs were 96.1 ± 73.9 cm3 in patients with moderate HF and 52.2 ± 29.7 cm3 in patients with severe HF (p <0.05). Subgroup analysis revealed a persistently smaller EFV in patients with HF regardless of coronary artery calcium scores, markers of renal function, lipid metabolism, fasting blood glucose, or body mass index. In conclusion, our data demonstrate a stepwise decrease in EFV in patients with impaired cardiac function.

Original languageEnglish (US)
Pages (from-to)397-401
Number of pages5
JournalAmerican Journal of Cardiology
Volume108
Issue number3
DOIs
StatePublished - Aug 1 2011
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Khawaja, T., Greer, C., Chokshi, A., Chavarria, N., Thadani, S., Jones, M., Schaefle, K., Bhatia, K., Collado, J. E., Shimbo, D., Einstein, A. J., & Schulze, P. C. (2011). Epicardial fat volume in patients with left ventricular systolic dysfunction. American Journal of Cardiology, 108(3), 397-401. https://doi.org/10.1016/j.amjcard.2011.03.058