Eosinophilic Fasciitis Associated with Tryptophan Ingestion

A Manifestation of Eosinophilia-Myalgia Syndrome

Marsha L. Gordon, Mark G. Lebwohl, Robert G. Phelps, Steven R. Cohen, Raul Fleischmajer

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Recently, the ingestion of tryptophan has been associated with eosinophilia-myalgia syndrome, which is characterized by eosinophilia, myalgias, and several less consistently reported findings. We treated 13 patients who exhibited clinical features of eosinophilic fasciitis who were taking high-dose tryptophan before the onset of clinical symptoms. Twelve patients exhibited eosinophilia, with eosinophil counts ranging from 0.13 to 0.88. The remaining patient was taking oral corticosteroids when her eosinophil count was determined. Eight patients complained of myalgias. Other symptoms included arthralgias, pruritus, cutaneous burning, weakness, fever, rashes, malaise, edema, muscle spasms, and alopecia. 5-Hydroxyindoleacetic acid levels were elevated in four of the eight urine specimens that were tested. Our findings suggest that previously diagnosed cases of eosinophilic fasciitis may represent variants of tryptophan-associated eosinophilia-myalgia syndrome. Derangements in the metabolism of tryptophan may play a role in sclerotic diseases.

Original languageEnglish (US)
Pages (from-to)217-220
Number of pages4
JournalArchives of Dermatology
Volume127
Issue number2
DOIs
StatePublished - 1991
Externally publishedYes

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Eosinophilia-Myalgia Syndrome
Tryptophan
Eating
Myalgia
Eosinophilia
Eosinophils
Hydroxyindoleacetic Acid
Alopecia
Arthralgia
Spasm
Pruritus
Exanthema
Edema
Adrenal Cortex Hormones
Fever
Urine
Skin
Eosinophilic Fasciitis

ASJC Scopus subject areas

  • Dermatology

Cite this

Eosinophilic Fasciitis Associated with Tryptophan Ingestion : A Manifestation of Eosinophilia-Myalgia Syndrome. / Gordon, Marsha L.; Lebwohl, Mark G.; Phelps, Robert G.; Cohen, Steven R.; Fleischmajer, Raul.

In: Archives of Dermatology, Vol. 127, No. 2, 1991, p. 217-220.

Research output: Contribution to journalArticle

Gordon, Marsha L. ; Lebwohl, Mark G. ; Phelps, Robert G. ; Cohen, Steven R. ; Fleischmajer, Raul. / Eosinophilic Fasciitis Associated with Tryptophan Ingestion : A Manifestation of Eosinophilia-Myalgia Syndrome. In: Archives of Dermatology. 1991 ; Vol. 127, No. 2. pp. 217-220.
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