Enzymatic transition state theory and transition state analogue design

Research output: Contribution to journalShort survey

94 Scopus citations

Abstract

Kinetic isotope effects linked to computational chemistry provide sufficient information to develop geometric and electrostatic potential maps of enzymatic transition states. These are blueprints for the design of transition state analogues. Chemically stable molecules that resemble the transition states provide a wealth of inhibitors with dissociation constants in the picomolar to femtomolar range. Several of these have entered clinical trials, and others are in preclinical development. Determination of KIEs coupled to computational and synthetic chemistry can contribute significantly to the development of a broad spectrum of useful enzymatic inhibitors.

Original languageEnglish (US)
Pages (from-to)28297-28300
Number of pages4
JournalJournal of Biological Chemistry
Volume282
Issue number39
DOIs
StatePublished - Sep 28 2007

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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