Enzymatic N-riboside scission in RNA and RNA precursors

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

N-ribohydrolases and transferases act on nucleosides, nucleotides and oligonucleotides to effect base removal. Advances in mechanistic and structural analysis have established that enzymes of N-riboside scission act by combinations of leaving-group and ribosyl activation. Alternative O-riboside substrates have been developed for mechanistic diagnosis. Transition-state structures have been determined, and powerful inhibitors have been designed from structural and transition-state information.

Original languageEnglish (US)
Pages (from-to)323-331
Number of pages9
JournalCurrent Opinion in Chemical Biology
Volume1
Issue number3
DOIs
StatePublished - Oct 1997

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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