Environmental lighting alters the infection process in an animal model of AIDS

D. L. McEachron, K. M. Tumas, K. J. Blank, M. B. Prystowsky

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

In this study, we examined the effects of altered environmental lighting on the infection process of a murine leukemia virus, E-55(+), which induces a thymic lymphoma/leukemia in 100% of BALB.K mice inoculated as adults. One to two weeks after inoculation, high levels of proviral DNA are usually found. This is followed by an asymptomatic period of many weeks during which proviral DNA becomes essentially undetectable. Leukemia develops approximately 28 weeks postinoculation. In this experiment, one group of mice was exposed a consistent 10L : 14D cycle while a second was maintained in constant light (LL). A third group was exposed to a rotating cycle characterized by phase shifting a 10L : 14D cycle every three 24-h days (rLD). All cycles began 2 weeks prior to inoculation and were maintained thereafter. Animals were sacrificed at 1, 5, 10, and 15 weeks, and hematopoietic tissue was examined for proviral DNA content. At 1 week, LL- and rLD-exposed animals showed considerably less proviral DNA in bone marrow and spleen compared with controls. At 15 weeks, thymuses from controls were showing signs of infection whereas tissue from LL and rLD mice remained at background levels. We conclude that environmental lighting does alter the infective pattern displayed by this retrovirus, although whether this effect is mediated by changes in the target stem cells or through immunoenhancement has not yet been determined.

Original languageEnglish (US)
Pages (from-to)947-952
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume51
Issue number4
DOIs
StatePublished - Aug 1995
Externally publishedYes

Keywords

  • AIDS
  • Animal model
  • Cell mediated
  • Circadian
  • Humoral
  • Immunity
  • Infection
  • Leukemia
  • Light
  • Mice
  • Resistance
  • TH
  • TH
  • Virus

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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