TY - JOUR
T1 - Environmental influence on neurodevelopmental disorders
T2 - Potential association of heavy metal exposure and autism
AU - Ijomone, Omamuyovwi M.
AU - Olung, Nzube F.
AU - Akingbade, Grace T.
AU - Okoh, Comfort O.A.
AU - Aschner, Michael
N1 - Funding Information:
OMI acknowledges the Young IBRO Regions Connecting Awards towards collaborative activities between The Neuro- Lab, Federal University of Technology Akure, Nigeria, and MA’s Lab, Albert Einstein College of Medicine, USA. MA is supported by National Institute of Health (NIH), USA grants; NIEHS R01 10563 , NIEHS R01 07331 and NIEHS R01 020852 .
Funding Information:
OMI acknowledges the Young IBRO Regions Connecting Awards towards collaborative activities between The Neuro- Lab, Federal University of Technology Akure, Nigeria, and MA's Lab, Albert Einstein College of Medicine, USA. MA is supported by National Institute of Health (NIH), USA grants; NIEHSR01 10563, NIEHS R01 07331 and NIEHS R01 020852.
Publisher Copyright:
© 2020 Elsevier GmbH
PY - 2020/12
Y1 - 2020/12
N2 - Environmental factors have been severally established to play major roles in the pathogenesis of neurodevelopmental disorders including autism spectrum disorder (ASD). ASD is a neurodevelopmental disorder that is associated with symptoms that reduce the quality of life of affected individuals such as social interaction deficit, cognitive impairment, intellectual disabilities, restricted and repetitive behavioural patterns. ASD pathogenesis has been associated with environmental and genetic factors that alter physiologic processes during development. Here, we review literatures highlighting the environmental impact on neurodevelopmental disorders, and mechanisms by which environmental toxins may influence neurodevelopment. Furthermore, this review discusses reports highlighting neurotoxic metals (specifically, lead, mercury, cadmium, nickel and manganese) as environmental risk factors in the aetiology of ASD. This work, thus suggests that improving the environment could be vital in the management of ASD.
AB - Environmental factors have been severally established to play major roles in the pathogenesis of neurodevelopmental disorders including autism spectrum disorder (ASD). ASD is a neurodevelopmental disorder that is associated with symptoms that reduce the quality of life of affected individuals such as social interaction deficit, cognitive impairment, intellectual disabilities, restricted and repetitive behavioural patterns. ASD pathogenesis has been associated with environmental and genetic factors that alter physiologic processes during development. Here, we review literatures highlighting the environmental impact on neurodevelopmental disorders, and mechanisms by which environmental toxins may influence neurodevelopment. Furthermore, this review discusses reports highlighting neurotoxic metals (specifically, lead, mercury, cadmium, nickel and manganese) as environmental risk factors in the aetiology of ASD. This work, thus suggests that improving the environment could be vital in the management of ASD.
KW - Autism
KW - Environment
KW - Metals
KW - Neurodevelopmental disorders
KW - Neurotoxicity
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U2 - 10.1016/j.jtemb.2020.126638
DO - 10.1016/j.jtemb.2020.126638
M3 - Review article
C2 - 32891009
AN - SCOPUS:85090005505
SN - 0946-672X
VL - 62
JO - Journal of Trace Elements in Medicine and Biology
JF - Journal of Trace Elements in Medicine and Biology
M1 - 126638
ER -