Environmental hydrocarbons produce degeneration in cat hypothalamus and optic tract

Herbert H. Schaumburg, Peter S. Spencer

Research output: Contribution to journalArticle

78 Scopus citations

Abstract

2,5-Hexanedione, the principal neurotoxic metabolite of the industrial solvents n-hexane and methyl n-butyl ketone causes axonal degeneration in the mammillary body and visual nuclei of cats. Prolonged, low-level exposure to hydrocarbons in the environment may cause premature deterioration in areas of the human brain vital for perception and behavior.

Original languageEnglish (US)
Pages (from-to)199-200
Number of pages2
JournalScience
Volume199
Issue number4325
DOIs
StatePublished - Jan 1 1978

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