Environmental hydrocarbons produce degeneration in cat hypothalamus and optic tract

Herbert H. Schaumburg, Peter S. Spencer

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

2,5-Hexanedione, the principal neurotoxic metabolite of the industrial solvents n-hexane and methyl n-butyl ketone causes axonal degeneration in the mammillary body and visual nuclei of cats. Prolonged, low-level exposure to hydrocarbons in the environment may cause premature deterioration in areas of the human brain vital for perception and behavior.

Original languageEnglish (US)
Pages (from-to)199-200
Number of pages2
JournalScience
Volume199
Issue number4325
StatePublished - 1978

Fingerprint

Methyl n-Butyl Ketone
Mammillary Bodies
Hydrocarbons
Hypothalamus
Cats
Brain
n-hexane
Optic Tract
2,5-hexanedione

ASJC Scopus subject areas

  • General

Cite this

Schaumburg, H. H., & Spencer, P. S. (1978). Environmental hydrocarbons produce degeneration in cat hypothalamus and optic tract. Science, 199(4325), 199-200.

Environmental hydrocarbons produce degeneration in cat hypothalamus and optic tract. / Schaumburg, Herbert H.; Spencer, Peter S.

In: Science, Vol. 199, No. 4325, 1978, p. 199-200.

Research output: Contribution to journalArticle

Schaumburg, HH & Spencer, PS 1978, 'Environmental hydrocarbons produce degeneration in cat hypothalamus and optic tract', Science, vol. 199, no. 4325, pp. 199-200.
Schaumburg, Herbert H. ; Spencer, Peter S. / Environmental hydrocarbons produce degeneration in cat hypothalamus and optic tract. In: Science. 1978 ; Vol. 199, No. 4325. pp. 199-200.
@article{948728a261ca44548f8ddd80e9ecdbc2,
title = "Environmental hydrocarbons produce degeneration in cat hypothalamus and optic tract",
abstract = "2,5-Hexanedione, the principal neurotoxic metabolite of the industrial solvents n-hexane and methyl n-butyl ketone causes axonal degeneration in the mammillary body and visual nuclei of cats. Prolonged, low-level exposure to hydrocarbons in the environment may cause premature deterioration in areas of the human brain vital for perception and behavior.",
author = "Schaumburg, {Herbert H.} and Spencer, {Peter S.}",
year = "1978",
language = "English (US)",
volume = "199",
pages = "199--200",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4325",

}

TY - JOUR

T1 - Environmental hydrocarbons produce degeneration in cat hypothalamus and optic tract

AU - Schaumburg, Herbert H.

AU - Spencer, Peter S.

PY - 1978

Y1 - 1978

N2 - 2,5-Hexanedione, the principal neurotoxic metabolite of the industrial solvents n-hexane and methyl n-butyl ketone causes axonal degeneration in the mammillary body and visual nuclei of cats. Prolonged, low-level exposure to hydrocarbons in the environment may cause premature deterioration in areas of the human brain vital for perception and behavior.

AB - 2,5-Hexanedione, the principal neurotoxic metabolite of the industrial solvents n-hexane and methyl n-butyl ketone causes axonal degeneration in the mammillary body and visual nuclei of cats. Prolonged, low-level exposure to hydrocarbons in the environment may cause premature deterioration in areas of the human brain vital for perception and behavior.

UR - http://www.scopus.com/inward/record.url?scp=0018200108&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018200108&partnerID=8YFLogxK

M3 - Article

VL - 199

SP - 199

EP - 200

JO - Science

JF - Science

SN - 0036-8075

IS - 4325

ER -