Environmental hydrocarbons produce degeneration in cat hypothalamus and optic tract

Herbert H. Schaumburg; Peter S. Spencer

doi:10.1126/science.413192

Environmental hydrocarbons produce degeneration in cat hypothalamus and optic tract

Herbert H. Schaumburg, Peter S. Spencer

Neurology

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

2,5-Hexanedione, the principal neurotoxic metabolite of the industrial solvents n-hexane and methyl n-butyl ketone causes axonal degeneration in the mammillary body and visual nuclei of cats. Prolonged, low-level exposure to hydrocarbons in the environment may cause premature deterioration in areas of the human brain vital for perception and behavior.

Original language	English (US)
Pages (from-to)	199-200
Number of pages	2
Journal	Science
Volume	199
Issue number	4325
DOIs	https://doi.org/10.1126/science.413192
State	Published - Jan 1 1978

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title = "Environmental hydrocarbons produce degeneration in cat hypothalamus and optic tract",

abstract = "2,5-Hexanedione, the principal neurotoxic metabolite of the industrial solvents n-hexane and methyl n-butyl ketone causes axonal degeneration in the mammillary body and visual nuclei of cats. Prolonged, low-level exposure to hydrocarbons in the environment may cause premature deterioration in areas of the human brain vital for perception and behavior.",

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AB - 2,5-Hexanedione, the principal neurotoxic metabolite of the industrial solvents n-hexane and methyl n-butyl ketone causes axonal degeneration in the mammillary body and visual nuclei of cats. Prolonged, low-level exposure to hydrocarbons in the environment may cause premature deterioration in areas of the human brain vital for perception and behavior.

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Environmental hydrocarbons produce degeneration in cat hypothalamus and optic tract

Abstract

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