Enriched environment promotes adult hippocampal neurogenesis through FGFRs

Marta Grońska-Pęski, J. Tiago Gonçalves, Jean M. Hébert

Research output: Contribution to journalArticlepeer-review

Abstract

The addition of new neurons to existing neural circuits in the adult brain remains of great interest to neurobiology because of its therapeutic implications. The premier model for studying this process has been the hippocampal dentate gyrus in mice, where new neurons are added to mature circuits during adulthood. Notably, external factors such as an enriched environment (EE) and exercise markedly increase hippocampal neurogenesis. Here, we demonstrate that EE acts by increasing fibroblast growth factor receptor (FGFR) function autonomously within neurogenic cells to expand their numbers in adult male and female mice. FGFRs activated by EE signal through their mediators, FGFR substrate (FRS), to induce stem cell proliferation, and through FRS and phospholipase Cc to increase the number of adult-born neurons, providing a mechanism for how EE promotes adult neurogenesis.

Original languageEnglish (US)
Pages (from-to)2899-2910
Number of pages12
JournalJournal of Neuroscience
Volume41
Issue number13
DOIs
StatePublished - Mar 31 2021

Keywords

  • Adult neurogenesis
  • Dentate gyrus
  • Environmental enrichment
  • Exercise
  • Fibroblast growth factor receptors
  • Neural stem cells

ASJC Scopus subject areas

  • Neuroscience(all)

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