@article{f90f8c535d584938bb2e953e4cf330fe,
title = "Enriched environment promotes adult hippocampal neurogenesis through FGFRs",
abstract = "The addition of new neurons to existing neural circuits in the adult brain remains of great interest to neurobiology because of its therapeutic implications. The premier model for studying this process has been the hippocampal dentate gyrus in mice, where new neurons are added to mature circuits during adulthood. Notably, external factors such as an enriched environment (EE) and exercise markedly increase hippocampal neurogenesis. Here, we demonstrate that EE acts by increasing fibroblast growth factor receptor (FGFR) function autonomously within neurogenic cells to expand their numbers in adult male and female mice. FGFRs activated by EE signal through their mediators, FGFR substrate (FRS), to induce stem cell proliferation, and through FRS and phospholipase Cc to increase the number of adult-born neurons, providing a mechanism for how EE promotes adult neurogenesis.",
keywords = "Adult neurogenesis, Dentate gyrus, Environmental enrichment, Exercise, Fibroblast growth factor receptors, Neural stem cells",
author = "Marta Gro{\'n}ska-P{\c e}ski and Gon{\c c}alves, {J. Tiago} and H{\'e}bert, {Jean M.}",
note = "Funding Information: Received Aug. 31, 2020; revised Dec. 27, 2020; accepted Jan. 7, 2021. Author contributions: M.G.-P., J.T.G., and J.M.H. designed research; M.G.-P. performed research; M.G.-P., J.T.G., and J.M.H. analyzed data; M.G.-P., J.T.G., and J.M.H. wrote the paper. This research was supported by The Einstein Training Program in Stem Cell Research from the Empire State Stem Cell Fund through New York State Department of Health Contract C34874GG (M.G.-P.), New York State Stem Cell Science Contract C32567GG (J.M.H.), and National Institutes of Health Grant MH-070596 (J.M.H.). We thank Philippe Soriano for providing Fgfr reporter mice. The authors declare no competing financial interests. Correspondence should be addressed to Jean M. H{\'e}bert at jean.hebert@einsteinmed.org. https://doi.org/10.1523/JNEUROSCI.2286-20.2021 Copyright {\textcopyright} 2021 the authors Publisher Copyright: Copyright {\textcopyright} 2021 the authors",
year = "2021",
month = mar,
day = "31",
doi = "10.1523/JNEUROSCI.2286-20.2021",
language = "English (US)",
volume = "41",
pages = "2899--2910",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "13",
}