Enkephalin convertase, an enkephalin synthesizing carboxypeptidase, has been further characterized and purified to virtual homogeneity from brain pituitary and adrenal chromaffin granules. Activity varies more than 10 fold in brain regions, generally reflecting enkephalin distribution. Enkephalin convertase activity is 20 fold higher in the anterior than the posterior pituitary, suggesting a role in the processing of other peptide hormones. Enkephalin convertase activity was not detected in any peripheral tissues.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)