Enkephalin convertase: A specific enkephalin synthesizing carboxypeptidase in adrenal chromaffin granules, brain, and pituitary gland

Lloyd D. Fricker, Surachai Supattapone, Solomon H. Snyder

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Abstract

Enkephalin convertase, an enkephalin synthesizing carboxypeptidase, has been further characterized and purified to virtual homogeneity from brain pituitary and adrenal chromaffin granules. Activity varies more than 10 fold in brain regions, generally reflecting enkephalin distribution. Enkephalin convertase activity is 20 fold higher in the anterior than the posterior pituitary, suggesting a role in the processing of other peptide hormones. Enkephalin convertase activity was not detected in any peripheral tissues.

Original languageEnglish (US)
Pages (from-to)1841-1844
Number of pages4
JournalLife Sciences
Volume31
Issue number16-17
DOIs
Publication statusPublished - Jan 1 1982
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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