Enhancement of viability of human peritoneal mesothelial cells with glutathione precursor: L-2-oxothiazolidine-4-carboxylate.

A. Breborowicz; J. Witowski; L. Martis; D. G. Oreopoulos

Enhancement of viability of human peritoneal mesothelial cells with glutathione precursor: L-2-oxothiazolidine-4-carboxylate.

A. Breborowicz, J. Witowski, L. Martis, D. G. Oreopoulos

Obstetrics & Gynecology and Women's Health

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

This study tested the effect of L-2-oxothiazolidine-4-carboxylate (procysteine), a precursor of the intracellular cysteine, on the function of human mesothelial cells (HMCs) in in vitro culture. Procysteine stimulated the proliferation of HMCs and decreased the spontaneous death rate of these cells. HMCs pretreated with procysteine were resistant to injury by free radicals. Procysteine also reversed the cytotoxic effects of a mixture of essential and nonessential amino acids on HMCs, such as increased susceptibility to injury by free radicals and inhibition of proliferation.

Original language	English (US)
Pages (from-to)	21-24
Number of pages	4
Journal	Advances in peritoneal dialysis. Conference on Peritoneal Dialysis
Volume	9
State	Published - 1993

ASJC Scopus subject areas

Medicine(all)

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abstract = "This study tested the effect of L-2-oxothiazolidine-4-carboxylate (procysteine), a precursor of the intracellular cysteine, on the function of human mesothelial cells (HMCs) in in vitro culture. Procysteine stimulated the proliferation of HMCs and decreased the spontaneous death rate of these cells. HMCs pretreated with procysteine were resistant to injury by free radicals. Procysteine also reversed the cytotoxic effects of a mixture of essential and nonessential amino acids on HMCs, such as increased susceptibility to injury by free radicals and inhibition of proliferation.",

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year = "1993",

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T1 - Enhancement of viability of human peritoneal mesothelial cells with glutathione precursor

T2 - L-2-oxothiazolidine-4-carboxylate.

AU - Breborowicz, A.

AU - Witowski, J.

AU - Martis, L.

AU - Oreopoulos, D. G.

PY - 1993

Y1 - 1993

N2 - This study tested the effect of L-2-oxothiazolidine-4-carboxylate (procysteine), a precursor of the intracellular cysteine, on the function of human mesothelial cells (HMCs) in in vitro culture. Procysteine stimulated the proliferation of HMCs and decreased the spontaneous death rate of these cells. HMCs pretreated with procysteine were resistant to injury by free radicals. Procysteine also reversed the cytotoxic effects of a mixture of essential and nonessential amino acids on HMCs, such as increased susceptibility to injury by free radicals and inhibition of proliferation.

AB - This study tested the effect of L-2-oxothiazolidine-4-carboxylate (procysteine), a precursor of the intracellular cysteine, on the function of human mesothelial cells (HMCs) in in vitro culture. Procysteine stimulated the proliferation of HMCs and decreased the spontaneous death rate of these cells. HMCs pretreated with procysteine were resistant to injury by free radicals. Procysteine also reversed the cytotoxic effects of a mixture of essential and nonessential amino acids on HMCs, such as increased susceptibility to injury by free radicals and inhibition of proliferation.

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AN - SCOPUS:0027356412

SN - 1197-8554

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SP - 21

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JO - Advances in peritoneal dialysis. Conference on Peritoneal Dialysis.

JF - Advances in peritoneal dialysis. Conference on Peritoneal Dialysis.

ER -

Enhancement of viability of human peritoneal mesothelial cells with glutathione precursor: L-2-oxothiazolidine-4-carboxylate.

Abstract

ASJC Scopus subject areas

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