Enhancement of radiation and chemotherapeutic drug responses by 2-deoxy-D-glucose in animal tumors.

Seema Gupta, Abdullah Farooque, J. S. Adhikari, Saurabh Singh, B. S. Dwarakanath

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27 Scopus citations

Abstract

The development of an approach based on the energy-linked modification of DNA repair and cellular recovery processes using 2-deoxy-D-glucose (2-DG; inhibitor of glycolytic ATP production) has shown promising results in a number of model systems of cancer. Following encouraging results on the tolerance and toxicity (acute as well as late effects) of the combination (2-DG and hypofractionated radiotherapy) in Phase I and II clinical trials, its efficacy is currently under evaluation in Phase III clinical trials for glioma patients. Since heterogeneous physiologic and metabolic status in tumors as well as host-tumor interactions influence the local tumor control, which coupled with systemic disturbances could determine the cure (long-term tumor free survival), investigations on the in vivo responses of tumors to the combined treatment have received considerable attention. This communication provides a brief overview on the in vivo studies related to radio- and chemosensitization of tumors by 2-DG, besides the normal tissue toxicity induced by the combined treatment of 2-DG and radiation or chemotherapeutic drugs.

Original languageEnglish (US)
Pages (from-to)S16-20
JournalJournal of cancer research and therapeutics
Volume5 Suppl 1
Publication statusPublished - Sep 2009

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ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Gupta, S., Farooque, A., Adhikari, J. S., Singh, S., & Dwarakanath, B. S. (2009). Enhancement of radiation and chemotherapeutic drug responses by 2-deoxy-D-glucose in animal tumors. Journal of cancer research and therapeutics, 5 Suppl 1, S16-20.