Enhancement of presynaptic dopamine efflux in brain by Δ9-tetrahydro-cannabinol is mediated by an endogenous opioid mechanism

E. L. Gardner, J. Chen, W. Paredes, D. Smith, J. Li, J. Lowinson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

The opiate antagonist naloxone, at doses as low as 0.1 mg/kg, antagonizes the enhancing effect of Δ9-tetrahydrocannabinol, the psychoactive agent in marijuana, on dopamine efflux in brain-reward-relevant dopamine circuits, implicating an endogenous opioid mechanism in marijuana's euphorigenic effect.

Original languageEnglish (US)
Title of host publicationNew leads in opioid research
Subtitle of host publicationproceedings of the International Narcotics Research Conference. ICS914
EditorsJ.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus, J.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus
PublisherElsevier Science Publishers B.V.
Number of pages1
ISBN (Print)044481213X
StatePublished - Jan 1 1990
EventThe International Narcotics Research Conference -
Duration: Jul 8 1989Jul 13 1989

Publication series

NameNew leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914

Other

OtherThe International Narcotics Research Conference
Period7/8/897/13/89

ASJC Scopus subject areas

  • Medicine(all)

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    Gardner, E. L., Chen, J., Paredes, W., Smith, D., Li, J., & Lowinson, J. (1990). Enhancement of presynaptic dopamine efflux in brain by Δ9-tetrahydro-cannabinol is mediated by an endogenous opioid mechanism. In J. M. Van Ree, A. H. Mulder, V. M. Wiegant, T. B. Van Wimersma Greidanus, J. M. Van Ree, A. H. Mulder, V. M. Wiegant, & T. B. Van Wimersma Greidanus (Eds.), New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914 (New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914). Elsevier Science Publishers B.V..