Enhancement of presynaptic dopamine efflux in brain by Δ9-tetrahydro-cannabinol is mediated by an endogenous opioid mechanism

E. L. Gardner, J. Chen, William Paredes, D. Smith, J. Li, J. Lowinson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

The opiate antagonist naloxone, at doses as low as 0.1 mg/kg, antagonizes the enhancing effect of Δ9-tetrahydrocannabinol, the psychoactive agent in marijuana, on dopamine efflux in brain-reward-relevant dopamine circuits, implicating an endogenous opioid mechanism in marijuana's euphorigenic effect.

Original languageEnglish (US)
Title of host publicationNew leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914
EditorsJ.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus, J.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus
PublisherElsevier Science Publishers B.V.
Pages243
Number of pages1
ISBN (Print)044481213X
StatePublished - 1990
EventThe International Narcotics Research Conference -
Duration: Jul 8 1989Jul 13 1989

Other

OtherThe International Narcotics Research Conference
Period7/8/897/13/89

Fingerprint

Cannabinol
Cannabis
Opioid Analgesics
Opiate Alkaloids
Dopamine
Dronabinol
Psychotropic Drugs
Brain
Naloxone
Reward

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gardner, E. L., Chen, J., Paredes, W., Smith, D., Li, J., & Lowinson, J. (1990). Enhancement of presynaptic dopamine efflux in brain by Δ9-tetrahydro-cannabinol is mediated by an endogenous opioid mechanism. In J. M. Van Ree, A. H. Mulder, V. M. Wiegant, T. B. Van Wimersma Greidanus, J. M. Van Ree, A. H. Mulder, V. M. Wiegant, ... T. B. Van Wimersma Greidanus (Eds.), New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914 (pp. 243). Elsevier Science Publishers B.V..

Enhancement of presynaptic dopamine efflux in brain by Δ9-tetrahydro-cannabinol is mediated by an endogenous opioid mechanism. / Gardner, E. L.; Chen, J.; Paredes, William; Smith, D.; Li, J.; Lowinson, J.

New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. ed. / J.M. Van Ree; A.H. Mulder; V.M. Wiegant; T.B. Van Wimersma Greidanus; J.M. Van Ree; A.H. Mulder; V.M. Wiegant; T.B. Van Wimersma Greidanus. Elsevier Science Publishers B.V., 1990. p. 243.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gardner, EL, Chen, J, Paredes, W, Smith, D, Li, J & Lowinson, J 1990, Enhancement of presynaptic dopamine efflux in brain by Δ9-tetrahydro-cannabinol is mediated by an endogenous opioid mechanism. in JM Van Ree, AH Mulder, VM Wiegant, TB Van Wimersma Greidanus, JM Van Ree, AH Mulder, VM Wiegant & TB Van Wimersma Greidanus (eds), New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. Elsevier Science Publishers B.V., pp. 243, The International Narcotics Research Conference, 7/8/89.
Gardner EL, Chen J, Paredes W, Smith D, Li J, Lowinson J. Enhancement of presynaptic dopamine efflux in brain by Δ9-tetrahydro-cannabinol is mediated by an endogenous opioid mechanism. In Van Ree JM, Mulder AH, Wiegant VM, Van Wimersma Greidanus TB, Van Ree JM, Mulder AH, Wiegant VM, Van Wimersma Greidanus TB, editors, New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. Elsevier Science Publishers B.V. 1990. p. 243
Gardner, E. L. ; Chen, J. ; Paredes, William ; Smith, D. ; Li, J. ; Lowinson, J. / Enhancement of presynaptic dopamine efflux in brain by Δ9-tetrahydro-cannabinol is mediated by an endogenous opioid mechanism. New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. editor / J.M. Van Ree ; A.H. Mulder ; V.M. Wiegant ; T.B. Van Wimersma Greidanus ; J.M. Van Ree ; A.H. Mulder ; V.M. Wiegant ; T.B. Van Wimersma Greidanus. Elsevier Science Publishers B.V., 1990. pp. 243
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AU - Lowinson, J.

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