TY - JOUR
T1 - Enhancement of nitric oxide synthesis by macrophages represents an additional mechanism of action for amphotericin B
AU - Mozaffarian, Neelufar
AU - Berman, Joan W.
AU - Casadevall, Arturo
PY - 1997/8
Y1 - 1997/8
N2 - Amphotericin B (AmB) enhanced nitrite synthesis by murine macrophage- like J774.16 cells in a dosedependent fashion. This effect was retained in the presence of Cryptococcus neoformans capsular polysaccharide, a known virulence factor. AmB and anticapsular antibody increased nitrite synergistically. In all cases, AmB required gamma interferon; C. neoformans cells were unable tO elicit nitrite, with or without AmB.
AB - Amphotericin B (AmB) enhanced nitrite synthesis by murine macrophage- like J774.16 cells in a dosedependent fashion. This effect was retained in the presence of Cryptococcus neoformans capsular polysaccharide, a known virulence factor. AmB and anticapsular antibody increased nitrite synergistically. In all cases, AmB required gamma interferon; C. neoformans cells were unable tO elicit nitrite, with or without AmB.
UR - http://www.scopus.com/inward/record.url?scp=0030855543&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030855543&partnerID=8YFLogxK
U2 - 10.1128/aac.41.8.1825
DO - 10.1128/aac.41.8.1825
M3 - Article
C2 - 9257771
AN - SCOPUS:0030855543
SN - 0066-4804
VL - 41
SP - 1825
EP - 1829
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 8
ER -
