Enhancement of nitric oxide synthesis by macrophages represents an additional mechanism of action for amphotericin B

Neelufar Mozaffarian, Joan W. Berman, Arturo Casadevall

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Amphotericin B (AmB) enhanced nitrite synthesis by murine macrophage- like J774.16 cells in a dosedependent fashion. This effect was retained in the presence of Cryptococcus neoformans capsular polysaccharide, a known virulence factor. AmB and anticapsular antibody increased nitrite synergistically. In all cases, AmB required gamma interferon; C. neoformans cells were unable tO elicit nitrite, with or without AmB.

Original languageEnglish (US)
Pages (from-to)1825-1829
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume41
Issue number8
StatePublished - Aug 1997

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Amphotericin B
Nitric Oxide
Nitrites
Macrophages
Cryptococcus neoformans
Virulence Factors
Interferon-gamma
Polysaccharides
Antibodies

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Enhancement of nitric oxide synthesis by macrophages represents an additional mechanism of action for amphotericin B. / Mozaffarian, Neelufar; Berman, Joan W.; Casadevall, Arturo.

In: Antimicrobial Agents and Chemotherapy, Vol. 41, No. 8, 08.1997, p. 1825-1829.

Research output: Contribution to journalArticle

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