Enhancement of HIV-1 infection by the capsular polysaccharide of Cryptococcus neoformans

M. Pettoello-Mantovani, A. Rubinstein, H. Goldstein, A. Casadevall, T. R. Kollmann, A. Rubinstein, H. Goldstein, A. Casadevall

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

Patients with AIDS who become infected with Cryptococcus neoformans have a poor prognosis. We speculated that the presence of cryptococcal capsular polysaccharide may enhance HIV-1 infection. In an in-vitro study, the presence of cryptococcal polysaccharide significantly increased (p<0·05) production of p24 antigen after infection of H9 cells with HIV-1-infected H9 cells. We also found similar results when lymphocytes from an HIV-1-infected patient were co-cultured with mononuclear cells from an uninfected individual. Our findings suggest a new pathogenic role for the capsular polysaccharide-namely, the capacity to enhance HIV-1 infectivity.

Original languageEnglish (US)
Pages (from-to)21-23
Number of pages3
JournalThe Lancet
Volume339
Issue number8784
DOIs
StatePublished - Jan 4 1992

ASJC Scopus subject areas

  • Medicine(all)

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