Enhancement of HIV-1 infection by the capsular polysaccharide of Cryptococcus neoformans

M. Pettoello-Mantovani, Arye Rubinstein, Harris Goldstein, A. Casadevall, T. R. Kollmann, A. Rubinstein, H. Goldstein, A. Casadevall

Research output: Contribution to journalArticle

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Abstract

Patients with AIDS who become infected with Cryptococcus neoformans have a poor prognosis. We speculated that the presence of cryptococcal capsular polysaccharide may enhance HIV-1 infection. In an in-vitro study, the presence of cryptococcal polysaccharide significantly increased (p<0·05) production of p24 antigen after infection of H9 cells with HIV-1-infected H9 cells. We also found similar results when lymphocytes from an HIV-1-infected patient were co-cultured with mononuclear cells from an uninfected individual. Our findings suggest a new pathogenic role for the capsular polysaccharide-namely, the capacity to enhance HIV-1 infectivity.

Original languageEnglish (US)
Pages (from-to)21-23
Number of pages3
JournalThe Lancet
Volume339
Issue number8784
DOIs
StatePublished - Jan 4 1992

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Cryptococcus neoformans
HIV Infections
Polysaccharides
HIV-1
Acquired Immunodeficiency Syndrome
Lymphocytes
Antigens
Infection
cryptococcal polysaccharide

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pettoello-Mantovani, M., Rubinstein, A., Goldstein, H., Casadevall, A., Kollmann, T. R., Rubinstein, A., ... Casadevall, A. (1992). Enhancement of HIV-1 infection by the capsular polysaccharide of Cryptococcus neoformans. The Lancet, 339(8784), 21-23. https://doi.org/10.1016/0140-6736(92)90142-P

Enhancement of HIV-1 infection by the capsular polysaccharide of Cryptococcus neoformans. / Pettoello-Mantovani, M.; Rubinstein, Arye; Goldstein, Harris; Casadevall, A.; Kollmann, T. R.; Rubinstein, A.; Goldstein, H.; Casadevall, A.

In: The Lancet, Vol. 339, No. 8784, 04.01.1992, p. 21-23.

Research output: Contribution to journalArticle

Pettoello-Mantovani, M, Rubinstein, A, Goldstein, H, Casadevall, A, Kollmann, TR, Rubinstein, A, Goldstein, H & Casadevall, A 1992, 'Enhancement of HIV-1 infection by the capsular polysaccharide of Cryptococcus neoformans', The Lancet, vol. 339, no. 8784, pp. 21-23. https://doi.org/10.1016/0140-6736(92)90142-P
Pettoello-Mantovani, M. ; Rubinstein, Arye ; Goldstein, Harris ; Casadevall, A. ; Kollmann, T. R. ; Rubinstein, A. ; Goldstein, H. ; Casadevall, A. / Enhancement of HIV-1 infection by the capsular polysaccharide of Cryptococcus neoformans. In: The Lancet. 1992 ; Vol. 339, No. 8784. pp. 21-23.
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