Enhancement of HIV-1 infection by the capsular polysaccharide of Cryptococcus neoformans

M. Pettoello-Mantovani; A. Rubinstein; H. Goldstein; A. Casadevall; T. R. Kollmann; A. Rubinstein; H. Goldstein; A. Casadevall

doi:10.1016/0140-6736(92)90142-P

Enhancement of HIV-1 infection by the capsular polysaccharide of Cryptococcus neoformans

M. Pettoello-Mantovani, A. Rubinstein, H. Goldstein, A. Casadevall, T. R. Kollmann, A. Rubinstein, H. Goldstein, A. Casadevall

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81 Scopus citations

Abstract

Patients with AIDS who become infected with Cryptococcus neoformans have a poor prognosis. We speculated that the presence of cryptococcal capsular polysaccharide may enhance HIV-1 infection. In an in-vitro study, the presence of cryptococcal polysaccharide significantly increased (p<0·05) production of p24 antigen after infection of H9 cells with HIV-1-infected H9 cells. We also found similar results when lymphocytes from an HIV-1-infected patient were co-cultured with mononuclear cells from an uninfected individual. Our findings suggest a new pathogenic role for the capsular polysaccharide-namely, the capacity to enhance HIV-1 infectivity.

Original language	English (US)
Pages (from-to)	21-23
Number of pages	3
Journal	The Lancet
Volume	339
Issue number	8784
DOIs	https://doi.org/10.1016/0140-6736(92)90142-P
State	Published - Jan 4 1992

ASJC Scopus subject areas

General Medicine

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0140-6736(92)90142-P

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title = "Enhancement of HIV-1 infection by the capsular polysaccharide of Cryptococcus neoformans",

abstract = "Patients with AIDS who become infected with Cryptococcus neoformans have a poor prognosis. We speculated that the presence of cryptococcal capsular polysaccharide may enhance HIV-1 infection. In an in-vitro study, the presence of cryptococcal polysaccharide significantly increased (p<0·05) production of p24 antigen after infection of H9 cells with HIV-1-infected H9 cells. We also found similar results when lymphocytes from an HIV-1-infected patient were co-cultured with mononuclear cells from an uninfected individual. Our findings suggest a new pathogenic role for the capsular polysaccharide-namely, the capacity to enhance HIV-1 infectivity.",

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T1 - Enhancement of HIV-1 infection by the capsular polysaccharide of Cryptococcus neoformans

AU - Pettoello-Mantovani, M.

AU - Rubinstein, A.

AU - Goldstein, H.

AU - Casadevall, A.

AU - Kollmann, T. R.

AU - Rubinstein, A.

AU - Goldstein, H.

AU - Casadevall, A.

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Y1 - 1992/1/4

N2 - Patients with AIDS who become infected with Cryptococcus neoformans have a poor prognosis. We speculated that the presence of cryptococcal capsular polysaccharide may enhance HIV-1 infection. In an in-vitro study, the presence of cryptococcal polysaccharide significantly increased (p<0·05) production of p24 antigen after infection of H9 cells with HIV-1-infected H9 cells. We also found similar results when lymphocytes from an HIV-1-infected patient were co-cultured with mononuclear cells from an uninfected individual. Our findings suggest a new pathogenic role for the capsular polysaccharide-namely, the capacity to enhance HIV-1 infectivity.

AB - Patients with AIDS who become infected with Cryptococcus neoformans have a poor prognosis. We speculated that the presence of cryptococcal capsular polysaccharide may enhance HIV-1 infection. In an in-vitro study, the presence of cryptococcal polysaccharide significantly increased (p<0·05) production of p24 antigen after infection of H9 cells with HIV-1-infected H9 cells. We also found similar results when lymphocytes from an HIV-1-infected patient were co-cultured with mononuclear cells from an uninfected individual. Our findings suggest a new pathogenic role for the capsular polysaccharide-namely, the capacity to enhance HIV-1 infectivity.

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Enhancement of HIV-1 infection by the capsular polysaccharide of Cryptococcus neoformans

Abstract

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