Enhanced Production of Functional Proteins from Defective Genes

Biao Xi; Fangxia Guan; David S. Lawrence

doi:10.1021/ja0318939

Enhanced Production of Functional Proteins from Defective Genes

Biao Xi, Fangxia Guan, David S. Lawrence

Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Nonsense mutations are associated with a host of genetic disorders. The protein products encoded by genes containing these mutations are either truncated or completely missing. Recently, members of the aminoglycoside family of antibiotics have been found to induce the ribosome to read past these inappropriately inserted stop codons, albeit at extremely modest efficiencies. We report herein a strategy that enhances the production of functional proteins from the corresponding mutated genes.

Original language	English (US)
Pages (from-to)	5660-5661
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	126
Issue number	18
DOIs	https://doi.org/10.1021/ja0318939
State	Published - May 12 2004

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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title = "Enhanced Production of Functional Proteins from Defective Genes",

abstract = "Nonsense mutations are associated with a host of genetic disorders. The protein products encoded by genes containing these mutations are either truncated or completely missing. Recently, members of the aminoglycoside family of antibiotics have been found to induce the ribosome to read past these inappropriately inserted stop codons, albeit at extremely modest efficiencies. We report herein a strategy that enhances the production of functional proteins from the corresponding mutated genes.",

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AB - Nonsense mutations are associated with a host of genetic disorders. The protein products encoded by genes containing these mutations are either truncated or completely missing. Recently, members of the aminoglycoside family of antibiotics have been found to induce the ribosome to read past these inappropriately inserted stop codons, albeit at extremely modest efficiencies. We report herein a strategy that enhances the production of functional proteins from the corresponding mutated genes.

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Enhanced Production of Functional Proteins from Defective Genes

Abstract

ASJC Scopus subject areas

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