Enhanced Production of Functional Proteins from Defective Genes

Biao Xi, Fangxia Guan, David S. Lawrence

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Nonsense mutations are associated with a host of genetic disorders. The protein products encoded by genes containing these mutations are either truncated or completely missing. Recently, members of the aminoglycoside family of antibiotics have been found to induce the ribosome to read past these inappropriately inserted stop codons, albeit at extremely modest efficiencies. We report herein a strategy that enhances the production of functional proteins from the corresponding mutated genes.

Original languageEnglish (US)
Pages (from-to)5660-5661
Number of pages2
JournalJournal of the American Chemical Society
Volume126
Issue number18
DOIs
Publication statusPublished - May 12 2004

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ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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