Enhanced antimicrobial activity of amine-phosphonium (N-P) hybrid polymers against gram-negative and gram-positive bacteria

Ruby Bansal, Rajiv Pathak, Diksha Jha, Pradeep Kumar, Hemant K. Gautam

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The authors report synthesis, characterization and evaluation of a series of linear polyethylenimine (lPEI)-grafted butyltriphenylphosphonium bromide (LBTP) polymers (N-P hybrid polymers) for their antimicrobial activity on various Gram-positive and Gram-negative bacteria. Polymers with ∼5.8-13.8% substitution of butyltriphenylphosphonium bromide (BTP) on the backbone of lPEI showed enhanced charge density as compared to native lPEI confirming the conjugation of BTP onto lPEI. These modified polymers displayed low hemolytic activity and excellent antimicrobial activity against these two types of bacteria with one of the modified polymers, LBTP-40, was found to exhibit high antimicrobial activity in all the strains.

Original languageEnglish (US)
Pages (from-to)84-89
Number of pages6
JournalInternational Journal of Polymeric Materials and Polymeric Biomaterials
Volume64
Issue number2
DOIs
StatePublished - Jul 20 2015
Externally publishedYes

Keywords

  • Antimicrobial activity
  • cationic polymers
  • linear polyethylenimine
  • phosphonium salts

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemical Engineering(all)
  • Polymers and Plastics

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