Enhanced antimicrobial activity of amine-phosphonium (N-P) hybrid polymers against gram-negative and gram-positive bacteria

Ruby Bansal; Rajiv Pathak; Diksha Jha; Pradeep Kumar; Hemant K. Gautam

doi:10.1080/00914037.2014.886246

Enhanced antimicrobial activity of amine-phosphonium (N-P) hybrid polymers against gram-negative and gram-positive bacteria

Ruby Bansal, Rajiv Pathak, Diksha Jha, Pradeep Kumar, Hemant K. Gautam

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The authors report synthesis, characterization and evaluation of a series of linear polyethylenimine (lPEI)-grafted butyltriphenylphosphonium bromide (LBTP) polymers (N-P hybrid polymers) for their antimicrobial activity on various Gram-positive and Gram-negative bacteria. Polymers with ∼5.8-13.8% substitution of butyltriphenylphosphonium bromide (BTP) on the backbone of lPEI showed enhanced charge density as compared to native lPEI confirming the conjugation of BTP onto lPEI. These modified polymers displayed low hemolytic activity and excellent antimicrobial activity against these two types of bacteria with one of the modified polymers, LBTP-40, was found to exhibit high antimicrobial activity in all the strains.

Original language	English (US)
Pages (from-to)	84-89
Number of pages	6
Journal	International Journal of Polymeric Materials and Polymeric Biomaterials
Volume	64
Issue number	2
DOIs	https://doi.org/10.1080/00914037.2014.886246
State	Published - Jul 20 2015
Externally published	Yes

Keywords

Antimicrobial activity
cationic polymers
linear polyethylenimine
phosphonium salts

ASJC Scopus subject areas

Analytical Chemistry
General Chemical Engineering
Polymers and Plastics

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10.1080/00914037.2014.886246

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abstract = "The authors report synthesis, characterization and evaluation of a series of linear polyethylenimine (lPEI)-grafted butyltriphenylphosphonium bromide (LBTP) polymers (N-P hybrid polymers) for their antimicrobial activity on various Gram-positive and Gram-negative bacteria. Polymers with ∼5.8-13.8% substitution of butyltriphenylphosphonium bromide (BTP) on the backbone of lPEI showed enhanced charge density as compared to native lPEI confirming the conjugation of BTP onto lPEI. These modified polymers displayed low hemolytic activity and excellent antimicrobial activity against these two types of bacteria with one of the modified polymers, LBTP-40, was found to exhibit high antimicrobial activity in all the strains.",

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AU - Bansal, Ruby

AU - Pathak, Rajiv

AU - Jha, Diksha

AU - Kumar, Pradeep

AU - Gautam, Hemant K.

PY - 2015/7/20

Y1 - 2015/7/20

N2 - The authors report synthesis, characterization and evaluation of a series of linear polyethylenimine (lPEI)-grafted butyltriphenylphosphonium bromide (LBTP) polymers (N-P hybrid polymers) for their antimicrobial activity on various Gram-positive and Gram-negative bacteria. Polymers with ∼5.8-13.8% substitution of butyltriphenylphosphonium bromide (BTP) on the backbone of lPEI showed enhanced charge density as compared to native lPEI confirming the conjugation of BTP onto lPEI. These modified polymers displayed low hemolytic activity and excellent antimicrobial activity against these two types of bacteria with one of the modified polymers, LBTP-40, was found to exhibit high antimicrobial activity in all the strains.

AB - The authors report synthesis, characterization and evaluation of a series of linear polyethylenimine (lPEI)-grafted butyltriphenylphosphonium bromide (LBTP) polymers (N-P hybrid polymers) for their antimicrobial activity on various Gram-positive and Gram-negative bacteria. Polymers with ∼5.8-13.8% substitution of butyltriphenylphosphonium bromide (BTP) on the backbone of lPEI showed enhanced charge density as compared to native lPEI confirming the conjugation of BTP onto lPEI. These modified polymers displayed low hemolytic activity and excellent antimicrobial activity against these two types of bacteria with one of the modified polymers, LBTP-40, was found to exhibit high antimicrobial activity in all the strains.

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KW - linear polyethylenimine

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Enhanced antimicrobial activity of amine-phosphonium (N-P) hybrid polymers against gram-negative and gram-positive bacteria

Abstract

Keywords

ASJC Scopus subject areas

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