TY - JOUR
T1 - Engulfment Is Required for Cell Competition
AU - Li, Wei
AU - Baker, Nicholas E.
N1 - Funding Information:
We thank L. Johnston, D. Shafritz, and Kristin White for discussions and comments on the manuscript and C. de la Cova for suggesting two-color engulfment assays. We thank Marc Freeman, C. Klambt, G. Morata, K. White, E. Schejter, R. Eisenman, and J. Treisman for Drosophila strains and M. Freeman and K. White for sharing unpublished information and reagents. Some other strains were obtained from the National Drosophila Stock Center at Bloomington, Indiana. Confocal microscopy was performed at the AIF, AECOM. This work was supported by a grant from the NIH (GM61230). N.E.B. is a scholar of the Irma T. Hirschl Trust for Biomedical Research. Some data in this paper are from a thesis to be submitted in partial fulfillment of the requirement for the degree of Doctor of Philosophy in the Graduate Division of Biomedical Sciences, Albert Einstein College of Medicine, Yeshiva University, USA.
PY - 2007/6/15
Y1 - 2007/6/15
N2 - Genetic mosaics that place cells in competition within tissues may model features of tissue repair and tumor development and may reveal mechanisms of growth regulation. In one example, normal cells eliminate "Minute" cells that have reduced ribosomal protein gene dose and grow at their expense, replacing the Minute cells within developing compartments. We describe genes that are required by wild-type cells to kill Minute neighbors in Drosophila. The engulfment genes draper, wasp, the phosphatidylserine receptor, mbc/dock180, and rac1 are needed in wild-type cells for the death of Minute neighbors, whose corpses are engulfed by wild-type cells. Wild-type cells can themselves be killed by cells with elevated engulfing activity. Thus engulfment genes act downstream of growth differences between cells to eliminate cells with reduced ribosomal gene dose.
AB - Genetic mosaics that place cells in competition within tissues may model features of tissue repair and tumor development and may reveal mechanisms of growth regulation. In one example, normal cells eliminate "Minute" cells that have reduced ribosomal protein gene dose and grow at their expense, replacing the Minute cells within developing compartments. We describe genes that are required by wild-type cells to kill Minute neighbors in Drosophila. The engulfment genes draper, wasp, the phosphatidylserine receptor, mbc/dock180, and rac1 are needed in wild-type cells for the death of Minute neighbors, whose corpses are engulfed by wild-type cells. Wild-type cells can themselves be killed by cells with elevated engulfing activity. Thus engulfment genes act downstream of growth differences between cells to eliminate cells with reduced ribosomal gene dose.
KW - CELLBIO
UR - http://www.scopus.com/inward/record.url?scp=34250025633&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34250025633&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2007.03.054
DO - 10.1016/j.cell.2007.03.054
M3 - Article
C2 - 17574031
AN - SCOPUS:34250025633
SN - 0092-8674
VL - 129
SP - 1215
EP - 1225
JO - Cell
JF - Cell
IS - 6
ER -