TY - CHAP
T1 - Engineering the Molecular Shape of PEG-Hemoglobin Adducts for Supraperfusion
AU - Acharya, Seetharama A.
AU - Intaglietta, Marcos
AU - Tsai, Amy G.
AU - Ananda, Kulal
AU - Meng, Fantao
PY - 2011/7/4
Y1 - 2011/7/4
KW - Blood losses, corrected - using volume-restitution fluids (plasma expanders, PEs)
KW - EAF HexaPEGylated Hb - a superperfusion agent
KW - EAF PEG-Hbs as mechanotransducers of e-NOS activity - and shear stress
KW - Engineering molecular shape of PEG-hemoglobin adducts - for supraperfusion
KW - Enzon DecaPEGylated Bovine Hb - nonhypertensive
KW - PEGylation of bovine Hb - increasing O2 affinity
KW - PEGylation, targeted - to surface amino groups
KW - Reductive PEGylation-induced weakening - of interdimeric interactions of tetrameric Hbs
KW - Role of pattern of PEGylation and total PEG mass - conjugated to Hb on O2 to tissues
KW - Thiolation-mediated EAF PEGylation of Hb - optimized for hexaPEGylation of oxy-Hb
UR - http://www.scopus.com/inward/record.url?scp=84862265574&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862265574&partnerID=8YFLogxK
U2 - 10.1002/9781119975427.ch25
DO - 10.1002/9781119975427.ch25
M3 - Chapter
AN - SCOPUS:84862265574
SN - 9780470686683
SP - 345
EP - 369
BT - Chemistry and Biochemistry of Oxygen Therapeutics
PB - John Wiley and Sons
ER -