Engineering the Molecular Shape of PEG-Hemoglobin Adducts for Supraperfusion

Seetharama A. Acharya, Marcos Intaglietta, Amy G. Tsai, Kulal Ananda, Fantao Meng

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
Original languageEnglish (US)
Title of host publicationChemistry and Biochemistry of Oxygen Therapeutics
Subtitle of host publicationFrom Transfusion to Artificial Blood
PublisherJohn Wiley and Sons
Pages345-369
Number of pages25
ISBN (Print)9780470686683
DOIs
StatePublished - Jul 4 2011

Keywords

  • Blood losses, corrected - using volume-restitution fluids (plasma expanders, PEs)
  • EAF HexaPEGylated Hb - a superperfusion agent
  • EAF PEG-Hbs as mechanotransducers of e-NOS activity - and shear stress
  • Engineering molecular shape of PEG-hemoglobin adducts - for supraperfusion
  • Enzon DecaPEGylated Bovine Hb - nonhypertensive
  • PEGylation of bovine Hb - increasing O2 affinity
  • PEGylation, targeted - to surface amino groups
  • Reductive PEGylation-induced weakening - of interdimeric interactions of tetrameric Hbs
  • Role of pattern of PEGylation and total PEG mass - conjugated to Hb on O2 to tissues
  • Thiolation-mediated EAF PEGylation of Hb - optimized for hexaPEGylation of oxy-Hb

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Acharya, S. A., Intaglietta, M., Tsai, A. G., Ananda, K., & Meng, F. (2011). Engineering the Molecular Shape of PEG-Hemoglobin Adducts for Supraperfusion. In Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood (pp. 345-369). John Wiley and Sons. https://doi.org/10.1002/9781119975427.ch25