Engineering the Molecular Shape of PEG-Hemoglobin Adducts for Supraperfusion

Seetharama A. Acharya, Marcos Intaglietta, Amy G. Tsai, Kulal Ananda, Fantao Meng

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
Original languageEnglish (US)
Title of host publicationChemistry and Biochemistry of Oxygen Therapeutics
Subtitle of host publicationFrom Transfusion to Artificial Blood
PublisherJohn Wiley and Sons
Number of pages25
ISBN (Print)9780470686683
StatePublished - Jul 4 2011


  • Blood losses, corrected - using volume-restitution fluids (plasma expanders, PEs)
  • EAF HexaPEGylated Hb - a superperfusion agent
  • EAF PEG-Hbs as mechanotransducers of e-NOS activity - and shear stress
  • Engineering molecular shape of PEG-hemoglobin adducts - for supraperfusion
  • Enzon DecaPEGylated Bovine Hb - nonhypertensive
  • PEGylation of bovine Hb - increasing O2 affinity
  • PEGylation, targeted - to surface amino groups
  • Reductive PEGylation-induced weakening - of interdimeric interactions of tetrameric Hbs
  • Role of pattern of PEGylation and total PEG mass - conjugated to Hb on O2 to tissues
  • Thiolation-mediated EAF PEGylation of Hb - optimized for hexaPEGylation of oxy-Hb

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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