Abstract
Large, multidomain RNA molecules are generally thought to fold following multiple pathways down rugged landscapes populated with intermediates and traps. A challenge to understanding RNA folding reactions is the complex relationships that exist between the structure of the RNA and its folding landscape. The identification of intermediate species that populate folding landscapes and characterization of elements of their structures are the key components to solving the RNA folding problem. This review explores recent studies that characterize the dominant pathways by which RNA folds, structural and dynamic features of intermediates that populate the folding landscape, and the energy barriers that separate the distinct steps of the folding process.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 655-666 |
| Number of pages | 12 |
| Journal | Current Opinion in Chemical Biology |
| Volume | 12 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2008 |
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ASJC Scopus subject areas
- Biochemistry
- Analytical Chemistry
Cite this
Energy barriers, pathways, and dynamics during folding of large, multidomain RNAs. / Shcherbakova, Inna; Mitra, Somdeb; Laederach, Alain; Brenowitz, Michael D.
In: Current Opinion in Chemical Biology, Vol. 12, No. 6, 12.2008, p. 655-666.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Energy barriers, pathways, and dynamics during folding of large, multidomain RNAs
AU - Shcherbakova, Inna
AU - Mitra, Somdeb
AU - Laederach, Alain
AU - Brenowitz, Michael D.
PY - 2008/12
Y1 - 2008/12
N2 - Large, multidomain RNA molecules are generally thought to fold following multiple pathways down rugged landscapes populated with intermediates and traps. A challenge to understanding RNA folding reactions is the complex relationships that exist between the structure of the RNA and its folding landscape. The identification of intermediate species that populate folding landscapes and characterization of elements of their structures are the key components to solving the RNA folding problem. This review explores recent studies that characterize the dominant pathways by which RNA folds, structural and dynamic features of intermediates that populate the folding landscape, and the energy barriers that separate the distinct steps of the folding process.
AB - Large, multidomain RNA molecules are generally thought to fold following multiple pathways down rugged landscapes populated with intermediates and traps. A challenge to understanding RNA folding reactions is the complex relationships that exist between the structure of the RNA and its folding landscape. The identification of intermediate species that populate folding landscapes and characterization of elements of their structures are the key components to solving the RNA folding problem. This review explores recent studies that characterize the dominant pathways by which RNA folds, structural and dynamic features of intermediates that populate the folding landscape, and the energy barriers that separate the distinct steps of the folding process.
UR - http://www.scopus.com/inward/record.url?scp=57549096731&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57549096731&partnerID=8YFLogxK
U2 - 10.1016/j.cbpa.2008.09.017
DO - 10.1016/j.cbpa.2008.09.017
M3 - Article
C2 - 18926923
AN - SCOPUS:57549096731
VL - 12
SP - 655
EP - 666
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
SN - 1367-5931
IS - 6
ER -