Energetic interventions for healthspan and resiliency with aging

Derek M. Huffman, Marissa J. Schafer, Nathan K. LeBrasseur

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Several behavioral and pharmacological strategies improve longevity, which is indicative of delayed organismal aging, with the most effective interventions extending both life- and healthspan. In free living creatures, maintaining health and function into old age requires resilience against a multitude of stressors. Conversely, in experimental settings, conventional housing of rodents limits exposure to such challenges, thereby obscuring an accurate assessment of resilience. Caloric restriction (CR) and exercise, as well as pharmacologic strategies (resveratrol, rapamycin, metformin, senolytics), are well established to improve indices of health and aging, but some paradoxical effects have been observed on resilience. For instance, CR potently retards the onset of age-related diseases, and improves lifespan to a greater extent than exercise in a variety of models. However, exercise has proven more consistently beneficial to organismal resilience against a broad array of stressors, including infections, surgery, wound healing and frailty. CR can improve cellular stress defenses and protect from frailty, but also impairs the response to infections, bed rest and healing. How an intervention will impact not only longevity, health and function, but also resiliency, is critical to better understanding translational implications. Thus, organismal robustness represents a critical, albeit understudied aspect of aging, which needs more careful attention in order to better inform on how putative age-delaying strategies will impact preservation of health and function in response to stressors with aging in humans.

Original languageEnglish (US)
Pages (from-to)73-83
Number of pages11
JournalExperimental Gerontology
Volume86
DOIs
StatePublished - Dec 15 2016

Fingerprint

Caloric Restriction
Aging of materials
Health
Bed Rest
Metformin
Sirolimus
Infection
Age of Onset
Wound Healing
Surgery
Rodentia
Pharmacology

Keywords

  • Aging
  • Caloric restriction
  • Diet
  • Exercise
  • Metformin
  • Rapamycin
  • Resiliency
  • Resveratrol
  • Robustness
  • Senolytics

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

Cite this

Energetic interventions for healthspan and resiliency with aging. / Huffman, Derek M.; Schafer, Marissa J.; LeBrasseur, Nathan K.

In: Experimental Gerontology, Vol. 86, 15.12.2016, p. 73-83.

Research output: Contribution to journalArticle

Huffman, Derek M. ; Schafer, Marissa J. ; LeBrasseur, Nathan K. / Energetic interventions for healthspan and resiliency with aging. In: Experimental Gerontology. 2016 ; Vol. 86. pp. 73-83.
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