Endothelin-1 receptor a blocker darusentan decreases hepatic changes and improves liver repopulation after cell transplantation in rats

Medicine & Life Sciences

• darusentan 100%
• Endothelin A Receptors 73%
• Cell Transplantation 58%
• Liver 27%
• Hepatic Stellate Cells 26%
• Hepatocytes 18%
• Ischemia 16%
• Kupffer Cells 13%
• Drug and Narcotic Control 12%
• retrorsine 9%
• Neutrophils 8%
• Dipeptidyl Peptidase 4 7%
• Desmin 6%
• Inbred F344 Rats 6%
• Vasoconstrictor Agents 5%
• Endothelin-1 5%
• Hepatectomy 5%
• Regulator Genes 5%
• Wounds and Injuries 5%
• Vasodilation 5%
• Cell- and Tissue-Based Therapy 5%
• Cell Adhesion 5%
• Transcriptional Activation 4%
• Vascular Endothelial Growth Factor A 4%
• Cell Culture Techniques 4%
• Oxidative Stress 3%
• Tumor Necrosis Factor-alpha 3%
• Gene Expression 3%
• Inflammation 3%
• Blood Vessels 3%
• Animals 2%
• In Vitro Techniques 2%
• Pharmaceutical Preparations 2%