Endothelin-1 and its role in the pathogenesis of infectious diseases

Brandi D. Freeman, Fabiana S. Machado, Herbert B. Tanowitz, Mahalia S. Desruisseaux

Research output: Contribution to journalReview article

37 Scopus citations

Abstract

Endothelins are potent regulators of vascular tone, which also have mitogenic, apoptotic, and immunomodulatory properties (Rubanyi and Polokoff, 1994; Kedzierski and Yanagisawa, 2001; Bagnato et al., 2011). Three isoforms of endothelin have been identified to date, with endothelin-1 (ET-1) being the best studied. ET-1 is classically considered a potent vasoconstrictor. However, in addition to the effects of ET-1 on vascular smooth muscle cells, the peptide is increasingly recognized as a pro-inflammatory cytokine (Teder and Noble, 2000; Sessa et al., 1991). ET-1 causes platelet aggregation and plays a role in the increased expression of leukocyte adhesion molecules, the synthesis of inflammatory mediators contributing to vascular dysfunction. High levels of ET-1 are found in alveolar macrophages, leukocytes (Sessa et al., 1991) and fibroblasts (Gu et al., 1991). Clinical and experimental data indicate that ET-1 is involved in the pathogenesis of sepsis (Tschaikowsky et al., 2000; Goto et al., 2012), viral and bacterial pneumonia (Schuetz et al., 2008; Samransamruajkit et al., 2002), Rickettsia conorii infections (Davi et al., 1995), Chagas disease (Petkova et al., 2000, 2001), and severe malaria (Dai et al., 2012; Machado et al., 2006; Wenisch et al., 1996a; Dietmann et al., 2008). In this minireview, we will discuss the role of endothelin in the pathogenesis of infectious processes.

Original languageEnglish (US)
Pages (from-to)110-119
Number of pages10
JournalLife Sciences
Volume118
Issue number2
DOIs
StatePublished - Nov 24 2014

Keywords

  • Blood brain barrier
  • Endothelin
  • Inflammation
  • Neuroinflammation
  • Parasitic disease
  • Pneumonia
  • Sepsis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint Dive into the research topics of 'Endothelin-1 and its role in the pathogenesis of infectious diseases'. Together they form a unique fingerprint.

  • Cite this

    Freeman, B. D., Machado, F. S., Tanowitz, H. B., & Desruisseaux, M. S. (2014). Endothelin-1 and its role in the pathogenesis of infectious diseases. Life Sciences, 118(2), 110-119. https://doi.org/10.1016/j.lfs.2014.04.021