Endothelin-1 and its role in the pathogenesis of infectious diseases

Brandi D. Freeman, Fabiana S. Machado, Herbert B. Tanowitz, Mahalia S. Desruisseaux

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Endothelins are potent regulators of vascular tone, which also have mitogenic, apoptotic, and immunomodulatory properties (Rubanyi and Polokoff, 1994; Kedzierski and Yanagisawa, 2001; Bagnato et al., 2011). Three isoforms of endothelin have been identified to date, with endothelin-1 (ET-1) being the best studied. ET-1 is classically considered a potent vasoconstrictor. However, in addition to the effects of ET-1 on vascular smooth muscle cells, the peptide is increasingly recognized as a pro-inflammatory cytokine (Teder and Noble, 2000; Sessa et al., 1991). ET-1 causes platelet aggregation and plays a role in the increased expression of leukocyte adhesion molecules, the synthesis of inflammatory mediators contributing to vascular dysfunction. High levels of ET-1 are found in alveolar macrophages, leukocytes (Sessa et al., 1991) and fibroblasts (Gu et al., 1991). Clinical and experimental data indicate that ET-1 is involved in the pathogenesis of sepsis (Tschaikowsky et al., 2000; Goto et al., 2012), viral and bacterial pneumonia (Schuetz et al., 2008; Samransamruajkit et al., 2002), Rickettsia conorii infections (Davi et al., 1995), Chagas disease (Petkova et al., 2000, 2001), and severe malaria (Dai et al., 2012; Machado et al., 2006; Wenisch et al., 1996a; Dietmann et al., 2008). In this minireview, we will discuss the role of endothelin in the pathogenesis of infectious processes.

Original languageEnglish (US)
Pages (from-to)110-119
Number of pages10
JournalLife Sciences
Volume118
Issue number2
DOIs
StatePublished - Nov 24 2014

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Endothelin-1
Communicable Diseases
Endothelins
Blood Vessels
Rickettsia Infections
Rickettsia conorii
Viral Pneumonia
Bacterial Pneumonia
Chagas Disease
Alveolar Macrophages
Cell Adhesion Molecules
Vasoconstrictor Agents
Fibroblasts
Platelets
Platelet Aggregation
Vascular Smooth Muscle
Malaria
Smooth Muscle Myocytes
Muscle
Sepsis

Keywords

  • Blood brain barrier
  • Endothelin
  • Inflammation
  • Neuroinflammation
  • Parasitic disease
  • Pneumonia
  • Sepsis

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Freeman, B. D., Machado, F. S., Tanowitz, H. B., & Desruisseaux, M. S. (2014). Endothelin-1 and its role in the pathogenesis of infectious diseases. Life Sciences, 118(2), 110-119. https://doi.org/10.1016/j.lfs.2014.04.021

Endothelin-1 and its role in the pathogenesis of infectious diseases. / Freeman, Brandi D.; Machado, Fabiana S.; Tanowitz, Herbert B.; Desruisseaux, Mahalia S.

In: Life Sciences, Vol. 118, No. 2, 24.11.2014, p. 110-119.

Research output: Contribution to journalArticle

Freeman, BD, Machado, FS, Tanowitz, HB & Desruisseaux, MS 2014, 'Endothelin-1 and its role in the pathogenesis of infectious diseases', Life Sciences, vol. 118, no. 2, pp. 110-119. https://doi.org/10.1016/j.lfs.2014.04.021
Freeman BD, Machado FS, Tanowitz HB, Desruisseaux MS. Endothelin-1 and its role in the pathogenesis of infectious diseases. Life Sciences. 2014 Nov 24;118(2):110-119. https://doi.org/10.1016/j.lfs.2014.04.021
Freeman, Brandi D. ; Machado, Fabiana S. ; Tanowitz, Herbert B. ; Desruisseaux, Mahalia S. / Endothelin-1 and its role in the pathogenesis of infectious diseases. In: Life Sciences. 2014 ; Vol. 118, No. 2. pp. 110-119.
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