Endothelial monocyte-activating polypeptide II, a tumor-derived cytokine that plays an important role in inflammation, apoptosis, and angiogenesis

A. C. Berger, G. Tang, H. R. Alexander, S. K. Libutti

Research output: Contribution to journalArticle

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Abstract

The interactions between a tumor and its surrounding environment are complex and characterized by a variety of factors. Tumors produce a number of proteins that enable them to recruit a vascular supply, invade into surrounding tissues, and metastasize to distant sites. The host, in turn, responds to these signals by producing its own repertoire of molecules that may either assist or prevent the actions of the tumor. A thorough understanding of this relationship is critical to the development of novel anti-cancer therapies. The tumor-derived cytokine endothelial monocyte-activating polypeptide II (EMAP-II) has profound effects on the tumor as well as on host response. These effects target the inflammatory cascade as well as the processes involved in angiogenesis. In this review the authors describe the current understanding of the role of EMAP-II in inflammation, apoptosis, and angiogenesis and use this molecule to illustrate the complex interactions that occur in the tumor microenvironment.

Original languageEnglish (US)
Pages (from-to)519-527
Number of pages9
JournalJournal of Immunotherapy
Volume23
Issue number5
DOIs
Publication statusPublished - Sep 19 2000

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Keywords

  • Angiogenesis
  • Apoptosis
  • EMAP-II
  • Inflammation
  • Tumor-host relationship

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Cancer Research

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