Endothelial apoptosis in critical illness

Research output: Contribution to journalArticle

Abstract

Endothelial injury is a hallmark of critical illness, and markers of endothelial perturbation correlate with severity of illness and final outcome. Available in vitro and experimental data suggest that endothelial apoptosis could play a role in critical illness. A review of recently described therapies for the critically ill demonstrates that all have an antiapoptotic effect on the endothelium. If the role of endothelial apoptosis is confirmed in future investigations, targeting this process with antiapoptotic therapies may lead to a breakthrough in the treatment of critically ill patients.

Original languageEnglish (US)
Pages (from-to)216-220
Number of pages5
JournalIntensivmedizin und Notfallmedizin
Volume41
Issue number4
DOIs
StatePublished - May 2004
Externally publishedYes

Fingerprint

Critical Illness
Apoptosis
Endothelium
Therapeutics
Wounds and Injuries

Keywords

  • Apoptosis
  • Critical illness
  • Endothelium

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Medicine(all)

Cite this

Endothelial apoptosis in critical illness. / Stefanec, Tihomir.

In: Intensivmedizin und Notfallmedizin, Vol. 41, No. 4, 05.2004, p. 216-220.

Research output: Contribution to journalArticle

@article{25471773e398423d946435dcf5806364,
title = "Endothelial apoptosis in critical illness",
abstract = "Endothelial injury is a hallmark of critical illness, and markers of endothelial perturbation correlate with severity of illness and final outcome. Available in vitro and experimental data suggest that endothelial apoptosis could play a role in critical illness. A review of recently described therapies for the critically ill demonstrates that all have an antiapoptotic effect on the endothelium. If the role of endothelial apoptosis is confirmed in future investigations, targeting this process with antiapoptotic therapies may lead to a breakthrough in the treatment of critically ill patients.",
keywords = "Apoptosis, Critical illness, Endothelium",
author = "Tihomir Stefanec",
year = "2004",
month = "5",
doi = "10.1007/s00390-004-0462-z",
language = "English (US)",
volume = "41",
pages = "216--220",
journal = "Intensivmedizin und Notfallmedizin",
issn = "0175-3851",
publisher = "D. Steinkopff-Verlag",
number = "4",

}

TY - JOUR

T1 - Endothelial apoptosis in critical illness

AU - Stefanec, Tihomir

PY - 2004/5

Y1 - 2004/5

N2 - Endothelial injury is a hallmark of critical illness, and markers of endothelial perturbation correlate with severity of illness and final outcome. Available in vitro and experimental data suggest that endothelial apoptosis could play a role in critical illness. A review of recently described therapies for the critically ill demonstrates that all have an antiapoptotic effect on the endothelium. If the role of endothelial apoptosis is confirmed in future investigations, targeting this process with antiapoptotic therapies may lead to a breakthrough in the treatment of critically ill patients.

AB - Endothelial injury is a hallmark of critical illness, and markers of endothelial perturbation correlate with severity of illness and final outcome. Available in vitro and experimental data suggest that endothelial apoptosis could play a role in critical illness. A review of recently described therapies for the critically ill demonstrates that all have an antiapoptotic effect on the endothelium. If the role of endothelial apoptosis is confirmed in future investigations, targeting this process with antiapoptotic therapies may lead to a breakthrough in the treatment of critically ill patients.

KW - Apoptosis

KW - Critical illness

KW - Endothelium

UR - http://www.scopus.com/inward/record.url?scp=2942590464&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2942590464&partnerID=8YFLogxK

U2 - 10.1007/s00390-004-0462-z

DO - 10.1007/s00390-004-0462-z

M3 - Article

AN - SCOPUS:2942590464

VL - 41

SP - 216

EP - 220

JO - Intensivmedizin und Notfallmedizin

JF - Intensivmedizin und Notfallmedizin

SN - 0175-3851

IS - 4

ER -