Endoscopic ultrasound-guided fine-needle aspiration diagnosis of secondary tumors involving the pancreas: An institution′s experience

Ahmed Alomari, Berrin Ustun, Harry Aslanian, Xinquan Ge, David Chhieng, Guoping Cai

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Pancreatic masses may seldom represent a metastasis or secondary involvement by lymphoproliferative disorders. Recognition of this uncommon occurrence may help render an accurate diagnosis and avoid diagnostic pitfalls during endoscopic ultrasound-guided fine needle aspiration (EUS-FNA). In this study, we review our experience in diagnosing secondary tumors involving the pancreas. Materials and Methods: The electronic database of cytopathology archives was searched for cases of secondary tumors involving the pancreas at our institution and a total of 31 cases were identified. The corresponding clinical presentations, imaging study findings, cytological diagnoses, the results of ancillary studies, and surgical follow-up, if available, were reviewed. Results: Nineteen of the patients were male and 12 female, with a mean age of 66 years. Twenty-Three patients (74%) had a prior history of malignancy, with the latency ranging from 6 months to 19 years. The secondary tumors involving the pancreas included metastatic carcinoma (24 cases), metastatic sarcoma (3 cases), diffuse large B-cell lymphoma (2 cases), and plasma cell neoplasm (2 cases). The most common metastatic tumors were renal cell carcinoma (8 cases) and lung carcinoma (7 cases). Correct diagnoses were rendered in 29 cases (94%). The remaining two cases were misclassified as primary pancreatic carcinoma. In both cases, the patients had no known history of malignancy, and no ancillary studies were performed. Conclusions: Secondary tumors involving the pancreas can be accurately diagnosed by EUS-FNA. Recognizing uncommon cytomorphologic features, knowing prior history of malignancy, and performing ancillary studies are the keys to improve diagnostic performance and avoid diagnostic pitfalls.

Original languageEnglish (US)
Article numberA1
JournalCytoJournal
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

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Endoscopic Ultrasound-Guided Fine Needle Aspiration
Pancreas
Neoplasms
Plasma Cell Neoplasms
Carcinoma
Lymphoproliferative Disorders
Lymphoma, Large B-Cell, Diffuse
Renal Cell Carcinoma
Sarcoma
Databases
Neoplasm Metastasis
Lung

Keywords

  • Ancillary study
  • endoscopic ultrasound
  • fine-needle aspiration
  • pancreas
  • secondary tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Endoscopic ultrasound-guided fine-needle aspiration diagnosis of secondary tumors involving the pancreas : An institution′s experience. / Alomari, Ahmed; Ustun, Berrin; Aslanian, Harry; Ge, Xinquan; Chhieng, David; Cai, Guoping.

In: CytoJournal, Vol. 13, No. 1, A1, 01.01.2016.

Research output: Contribution to journalArticle

Alomari, Ahmed ; Ustun, Berrin ; Aslanian, Harry ; Ge, Xinquan ; Chhieng, David ; Cai, Guoping. / Endoscopic ultrasound-guided fine-needle aspiration diagnosis of secondary tumors involving the pancreas : An institution′s experience. In: CytoJournal. 2016 ; Vol. 13, No. 1.
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