TY - JOUR
T1 - Endoplasmic reticulum architecture
T2 - structures in flux
AU - Borgese, Nica
AU - Francolini, Maura
AU - Snapp, Erik
N1 - Funding Information:
We thank Francesca Lombardo for collaboration in the EM studies (panels a-e of Figure 1 ). Work in the laboratory of N. Borgese was supported by grants from Ministero della Istruzione, Università e Ricerca (MIUR), Ministero della Sanità (ALS grant 2002) and CNR grant ME-P02-IN-C2-M001 to the Institute of Neuroscience. Erik Snapp is an Ellison Medical Foundation New Scholar in Aging.
PY - 2006/8
Y1 - 2006/8
N2 - The endoplasmic reticulum (ER) is a dynamic pleiomorphic organelle containing continuous but distinct subdomains. The diversity of ER structures parallels its many functions, including secretory protein biogenesis, lipid synthesis, drug metabolism and Ca2+ signaling. Recent studies are revealing how elaborate ER structures arise in response to subtle changes in protein levels, dynamics, and interactions as well as in response to alterations in cytosolic ion concentrations. Subdomain formation appears to be governed by principles of self-organization. Once formed, ER subdomains remain malleable and can be rapidly transformed into alternative structures in response to altered conditions. The mechanisms that modulate ER structure are likely to be important for the generation of the characteristic shapes of other organelles.
AB - The endoplasmic reticulum (ER) is a dynamic pleiomorphic organelle containing continuous but distinct subdomains. The diversity of ER structures parallels its many functions, including secretory protein biogenesis, lipid synthesis, drug metabolism and Ca2+ signaling. Recent studies are revealing how elaborate ER structures arise in response to subtle changes in protein levels, dynamics, and interactions as well as in response to alterations in cytosolic ion concentrations. Subdomain formation appears to be governed by principles of self-organization. Once formed, ER subdomains remain malleable and can be rapidly transformed into alternative structures in response to altered conditions. The mechanisms that modulate ER structure are likely to be important for the generation of the characteristic shapes of other organelles.
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U2 - 10.1016/j.ceb.2006.06.008
DO - 10.1016/j.ceb.2006.06.008
M3 - Review article
C2 - 16806883
AN - SCOPUS:33745752369
SN - 0955-0674
VL - 18
SP - 358
EP - 364
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 4
ER -