Endometrioid adenocarcinoma of the ovary and long-term tamoxifen therapy: A coincidence or a cause for concern?

Dennis Yi-Shin Kuo, J. Jones, A. L. Fields, C. D. Runowicz, G. L. Goldberg

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In recent years, the extensive usage of tamoxifen in patients with breast cancer has led us to acquire a gnat deal of knowledge of its effects on various organs in the gynecological system, especially the effect on the endometrium and the increased risk of endometrial cancer. Information on the possible potential carcinogenic effect of tamoxifen on the ovary, however, has been limited, mainly because of the overall low incidence of ovarian carcinoma. In addition, there is the confounding variable posed by the diverse hereditary breast and ovarian cancer syndromes which tend to occur in a younger age group. Here, we present a case of a postmenopausal woman who was treated for six years with tamoxifen for breast cancer before being diagnosed with endometrioid carcinoma of the ovary. We believe that given the age of the patient and the duration of tamoxifen use, the occurrence of ovarian endometrioid carcinoma may be associated with long-term tamoxifen use.

Original languageEnglish (US)
Pages (from-to)457-460
Number of pages4
JournalEuropean Journal of Gynaecological Oncology
Volume18
Issue number6
StatePublished - 1997

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Endometrioid Carcinoma
Tamoxifen
Ovary
Hereditary Breast and Ovarian Cancer Syndrome
Breast Neoplasms
Therapeutics
Confounding Factors (Epidemiology)
Endometrial Neoplasms
Endometrium
Age Groups
Carcinoma
Incidence

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Endometrioid adenocarcinoma of the ovary and long-term tamoxifen therapy : A coincidence or a cause for concern? / Kuo, Dennis Yi-Shin; Jones, J.; Fields, A. L.; Runowicz, C. D.; Goldberg, G. L.

In: European Journal of Gynaecological Oncology, Vol. 18, No. 6, 1997, p. 457-460.

Research output: Contribution to journalArticle

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