Endometrial carcinoma

Antonio Di Cristofano, Lora Hedrick Ellenson

Research output: Chapter in Book/Report/Conference proceedingChapter

150 Scopus citations

Abstract

Endometrial carcinoma, a common malignancy of the female genital tract, is composed of a number of tumor types with different light-microscopic features, molecular genetic alterations, and prognoses. In addition, hormonal influences significantly impact growth regulatory pathways and interact with genetic alterations in the pathogenesis of at least some types of endometrial carcinoma. These factors have complicated the analyses of endometrial carcinoma, but over the past decades, awareness of the different types of endometrial carcinoma, in addition to careful clinicopathological studies, molecular analyses, and animal studies of the biological underpinnings of the different tumor types, has increased. We present the current understanding of endometrial carcinoma, from a molecular vantage point, highlighting what are presently thought to be the fundamental pathways involved in the development and progression of the major types of endometrial carcinoma.

Original languageEnglish (US)
Title of host publicationAnnual Review of Pathology
Subtitle of host publicationMechanisms of Disease
PublisherAnnual Reviews Inc.
Pages57-85
Number of pages29
ISBN (Print)0824343026, 9780824343026
DOIs
StatePublished - Jan 1 2007
Externally publishedYes

Publication series

NameAnnual Review of Pathology
Volume2
ISSN (Print)1553-4006
ISSN (Electronic)1553-4014

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Keywords

  • Endometrioid
  • Estrogen receptor
  • Molecular genetics
  • Mouse models
  • PTEN
  • Serous

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Di Cristofano, A., & Ellenson, L. H. (2007). Endometrial carcinoma. In Annual Review of Pathology: Mechanisms of Disease (pp. 57-85). (Annual Review of Pathology; Vol. 2). Annual Reviews Inc.. https://doi.org/10.1146/annurev.pathol.2.010506.091905