Endoleak after endovascular graft repair of experimental aortic aneurysms: Does coil embolization with angiographic 'seal' lower intraaneurysmal pressure?

B. Marty, L. A. Sanchez, T. Ohki, R. A. Wain, P. L. Faries, Jacob Cynamon, M. L. Marin, F. J. Veith, W. Wisselink, E. Ascher, M. F. Silane

Research output: Contribution to journalArticle

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Abstract

Purpose: To investigate the relation between endoleaks and intraaneurysmal pressure (IAP) and the effect of coil embolization in the management of endoleaks. Methods: The infrarenal aorta of a dog (n = 15) was replaced by a polytetrafluoroethylene aneurysm containing a pressure transducer. Group I (n = 4) had untreated aneurysms. Group II (n = 4) had endovascularly excluded aneurysms without an endoleak. Group III (n = 7) had aneurysms excluded by means of grafts with a defect that represented the source of an endoleak. After 4 weeks of follow-up study, the endoleaks in group III dogs were subjected to coil embolization. Systolic IAP was measured daily and expressed as a ratio of systolic blood pressure obtained from a forelimb cuff. Arteriography, duplex ultrasonography, and spiral contrast computed tomography were performed to evaluate endoleaks. Results: In group I, the IAP remained close to systolic blood pressure (ratio of 0.96 ± 0.06), whereas in group II the IAP ratio showed a decline to 0.34 ± 0.16 (p = 0.0009 group I versus II). After an initial decrease, the IAP ratio in group III stabilized at 0.75 ± 0.18 (p = 0.003, group II versus III). Aneurysms with an endoleak remained pulsatile with a pulse pressure of 30 ± 16 mm Hg, which was less than that of untreated aneurysms (62 ± 15 mm Hg; p < 0.001 group I versus III). Arteriography and computed tomography revealed 'sealing' of endoleaks after coil embolization, but IAP ratio did not decrease (0.76 ± 0.14) after coil embolization. Conclusions: Incomplete endovascular aneurysm exclusion caused by an endoleak fails to reduce IAP ration and may subject the aneurysm to a continued risk for rupture. Although coil embolization resulted in angiographic and computed tomographic sealing, it failed to reduce IAP ratio.

Original languageEnglish (US)
Pages (from-to)454-462
Number of pages9
JournalJournal of Vascular Surgery
Volume27
Issue number3
DOIs
StatePublished - 1998

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Endoleak
Aortic Aneurysm
Aneurysm
Transplants
Pressure
Blood Pressure
Angiography
Dogs
Pressure Transducers
Forelimb
Spiral Computed Tomography
Polytetrafluoroethylene
Aorta
Rupture
Ultrasonography
Tomography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Endoleak after endovascular graft repair of experimental aortic aneurysms : Does coil embolization with angiographic 'seal' lower intraaneurysmal pressure? / Marty, B.; Sanchez, L. A.; Ohki, T.; Wain, R. A.; Faries, P. L.; Cynamon, Jacob; Marin, M. L.; Veith, F. J.; Wisselink, W.; Ascher, E.; Silane, M. F.

In: Journal of Vascular Surgery, Vol. 27, No. 3, 1998, p. 454-462.

Research output: Contribution to journalArticle

Marty, B. ; Sanchez, L. A. ; Ohki, T. ; Wain, R. A. ; Faries, P. L. ; Cynamon, Jacob ; Marin, M. L. ; Veith, F. J. ; Wisselink, W. ; Ascher, E. ; Silane, M. F. / Endoleak after endovascular graft repair of experimental aortic aneurysms : Does coil embolization with angiographic 'seal' lower intraaneurysmal pressure?. In: Journal of Vascular Surgery. 1998 ; Vol. 27, No. 3. pp. 454-462.
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abstract = "Purpose: To investigate the relation between endoleaks and intraaneurysmal pressure (IAP) and the effect of coil embolization in the management of endoleaks. Methods: The infrarenal aorta of a dog (n = 15) was replaced by a polytetrafluoroethylene aneurysm containing a pressure transducer. Group I (n = 4) had untreated aneurysms. Group II (n = 4) had endovascularly excluded aneurysms without an endoleak. Group III (n = 7) had aneurysms excluded by means of grafts with a defect that represented the source of an endoleak. After 4 weeks of follow-up study, the endoleaks in group III dogs were subjected to coil embolization. Systolic IAP was measured daily and expressed as a ratio of systolic blood pressure obtained from a forelimb cuff. Arteriography, duplex ultrasonography, and spiral contrast computed tomography were performed to evaluate endoleaks. Results: In group I, the IAP remained close to systolic blood pressure (ratio of 0.96 ± 0.06), whereas in group II the IAP ratio showed a decline to 0.34 ± 0.16 (p = 0.0009 group I versus II). After an initial decrease, the IAP ratio in group III stabilized at 0.75 ± 0.18 (p = 0.003, group II versus III). Aneurysms with an endoleak remained pulsatile with a pulse pressure of 30 ± 16 mm Hg, which was less than that of untreated aneurysms (62 ± 15 mm Hg; p < 0.001 group I versus III). Arteriography and computed tomography revealed 'sealing' of endoleaks after coil embolization, but IAP ratio did not decrease (0.76 ± 0.14) after coil embolization. Conclusions: Incomplete endovascular aneurysm exclusion caused by an endoleak fails to reduce IAP ration and may subject the aneurysm to a continued risk for rupture. Although coil embolization resulted in angiographic and computed tomographic sealing, it failed to reduce IAP ratio.",
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T2 - Does coil embolization with angiographic 'seal' lower intraaneurysmal pressure?

AU - Marty, B.

AU - Sanchez, L. A.

AU - Ohki, T.

AU - Wain, R. A.

AU - Faries, P. L.

AU - Cynamon, Jacob

AU - Marin, M. L.

AU - Veith, F. J.

AU - Wisselink, W.

AU - Ascher, E.

AU - Silane, M. F.

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N2 - Purpose: To investigate the relation between endoleaks and intraaneurysmal pressure (IAP) and the effect of coil embolization in the management of endoleaks. Methods: The infrarenal aorta of a dog (n = 15) was replaced by a polytetrafluoroethylene aneurysm containing a pressure transducer. Group I (n = 4) had untreated aneurysms. Group II (n = 4) had endovascularly excluded aneurysms without an endoleak. Group III (n = 7) had aneurysms excluded by means of grafts with a defect that represented the source of an endoleak. After 4 weeks of follow-up study, the endoleaks in group III dogs were subjected to coil embolization. Systolic IAP was measured daily and expressed as a ratio of systolic blood pressure obtained from a forelimb cuff. Arteriography, duplex ultrasonography, and spiral contrast computed tomography were performed to evaluate endoleaks. Results: In group I, the IAP remained close to systolic blood pressure (ratio of 0.96 ± 0.06), whereas in group II the IAP ratio showed a decline to 0.34 ± 0.16 (p = 0.0009 group I versus II). After an initial decrease, the IAP ratio in group III stabilized at 0.75 ± 0.18 (p = 0.003, group II versus III). Aneurysms with an endoleak remained pulsatile with a pulse pressure of 30 ± 16 mm Hg, which was less than that of untreated aneurysms (62 ± 15 mm Hg; p < 0.001 group I versus III). Arteriography and computed tomography revealed 'sealing' of endoleaks after coil embolization, but IAP ratio did not decrease (0.76 ± 0.14) after coil embolization. Conclusions: Incomplete endovascular aneurysm exclusion caused by an endoleak fails to reduce IAP ration and may subject the aneurysm to a continued risk for rupture. Although coil embolization resulted in angiographic and computed tomographic sealing, it failed to reduce IAP ratio.

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