Abstract
A role for endogenous cholecystokinin (CCK) in the control of gastric emptying of liquid glucose and maltose test meals in rhesus monkeys was assessed. Intragastric administration of a dose range (10-100 μg/kg) of the CCK(A) receptor antagonist devazepide produced a dose dependent acceleration of the emptying of 100 ml 300 mOsm test meals of glucose and maltose but had no effect on the emptying of a hyperosmotic (750 mOsm) NaCl solution. At the 100 μg/kg dose, the emptying of glucose and maltose meals were as rapid as the emptying of physiological NaCl. These data expand the demonstrated role of endogenous CCK in the slowing of gastric emptying of nutrients in rhesus monkeys to carbohydrates and suggest that previous negative results were due to the hyperosmotic nature of the glucose solutions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 547-550 |
| Number of pages | 4 |
| Journal | Peptides |
| Volume | 18 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1997 |
| Externally published | Yes |
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Keywords
- CCK(A)
- Devazepide
- Gastric emptying
- Rhesus monkeys
ASJC Scopus subject areas
- Biochemistry
- Endocrinology
- Physiology
- Cellular and Molecular Neuroscience
Cite this
Endogenous CCK in the control of gastric emptying of glucose and maltose. / Moran, Timothy H.; Field, Douglas G.; Knipp, Susan; Carrigan, Timothy S.; Schwartz, Gary J.
In: Peptides, Vol. 18, No. 4, 1997, p. 547-550.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endogenous CCK in the control of gastric emptying of glucose and maltose
AU - Moran, Timothy H.
AU - Field, Douglas G.
AU - Knipp, Susan
AU - Carrigan, Timothy S.
AU - Schwartz, Gary J.
PY - 1997
Y1 - 1997
N2 - A role for endogenous cholecystokinin (CCK) in the control of gastric emptying of liquid glucose and maltose test meals in rhesus monkeys was assessed. Intragastric administration of a dose range (10-100 μg/kg) of the CCK(A) receptor antagonist devazepide produced a dose dependent acceleration of the emptying of 100 ml 300 mOsm test meals of glucose and maltose but had no effect on the emptying of a hyperosmotic (750 mOsm) NaCl solution. At the 100 μg/kg dose, the emptying of glucose and maltose meals were as rapid as the emptying of physiological NaCl. These data expand the demonstrated role of endogenous CCK in the slowing of gastric emptying of nutrients in rhesus monkeys to carbohydrates and suggest that previous negative results were due to the hyperosmotic nature of the glucose solutions.
AB - A role for endogenous cholecystokinin (CCK) in the control of gastric emptying of liquid glucose and maltose test meals in rhesus monkeys was assessed. Intragastric administration of a dose range (10-100 μg/kg) of the CCK(A) receptor antagonist devazepide produced a dose dependent acceleration of the emptying of 100 ml 300 mOsm test meals of glucose and maltose but had no effect on the emptying of a hyperosmotic (750 mOsm) NaCl solution. At the 100 μg/kg dose, the emptying of glucose and maltose meals were as rapid as the emptying of physiological NaCl. These data expand the demonstrated role of endogenous CCK in the slowing of gastric emptying of nutrients in rhesus monkeys to carbohydrates and suggest that previous negative results were due to the hyperosmotic nature of the glucose solutions.
KW - CCK(A)
KW - Devazepide
KW - Gastric emptying
KW - Rhesus monkeys
UR - http://www.scopus.com/inward/record.url?scp=0030992231&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030992231&partnerID=8YFLogxK
U2 - 10.1016/S0196-9781(97)00062-4
DO - 10.1016/S0196-9781(97)00062-4
M3 - Article
C2 - 9210174
AN - SCOPUS:0030992231
VL - 18
SP - 547
EP - 550
JO - Peptides
JF - Peptides
SN - 0196-9781
IS - 4
ER -