Endogenous CCK in the control of gastric emptying of glucose and maltose

Timothy H. Moran, Douglas G. Field, Susan Knipp, Timothy S. Carrigan, Gary J. Schwartz

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A role for endogenous cholecystokinin (CCK) in the control of gastric emptying of liquid glucose and maltose test meals in rhesus monkeys was assessed. Intragastric administration of a dose range (10-100 μg/kg) of the CCK(A) receptor antagonist devazepide produced a dose dependent acceleration of the emptying of 100 ml 300 mOsm test meals of glucose and maltose but had no effect on the emptying of a hyperosmotic (750 mOsm) NaCl solution. At the 100 μg/kg dose, the emptying of glucose and maltose meals were as rapid as the emptying of physiological NaCl. These data expand the demonstrated role of endogenous CCK in the slowing of gastric emptying of nutrients in rhesus monkeys to carbohydrates and suggest that previous negative results were due to the hyperosmotic nature of the glucose solutions.

Original languageEnglish (US)
Pages (from-to)547-550
Number of pages4
JournalPeptides
Volume18
Issue number4
DOIs
StatePublished - 1997
Externally publishedYes

Fingerprint

Maltose
Gastric Emptying
Cholecystokinin
Meals
Glucose
Macaca mulatta
Devazepide
Cholecystokinin A Receptor
Nutrients
Carbohydrates
Food
Liquids

Keywords

  • CCK(A)
  • Devazepide
  • Gastric emptying
  • Rhesus monkeys

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Endogenous CCK in the control of gastric emptying of glucose and maltose. / Moran, Timothy H.; Field, Douglas G.; Knipp, Susan; Carrigan, Timothy S.; Schwartz, Gary J.

In: Peptides, Vol. 18, No. 4, 1997, p. 547-550.

Research output: Contribution to journalArticle

Moran, Timothy H. ; Field, Douglas G. ; Knipp, Susan ; Carrigan, Timothy S. ; Schwartz, Gary J. / Endogenous CCK in the control of gastric emptying of glucose and maltose. In: Peptides. 1997 ; Vol. 18, No. 4. pp. 547-550.
@article{7df7788b184b4554ba093e8883981e36,
title = "Endogenous CCK in the control of gastric emptying of glucose and maltose",
abstract = "A role for endogenous cholecystokinin (CCK) in the control of gastric emptying of liquid glucose and maltose test meals in rhesus monkeys was assessed. Intragastric administration of a dose range (10-100 μg/kg) of the CCK(A) receptor antagonist devazepide produced a dose dependent acceleration of the emptying of 100 ml 300 mOsm test meals of glucose and maltose but had no effect on the emptying of a hyperosmotic (750 mOsm) NaCl solution. At the 100 μg/kg dose, the emptying of glucose and maltose meals were as rapid as the emptying of physiological NaCl. These data expand the demonstrated role of endogenous CCK in the slowing of gastric emptying of nutrients in rhesus monkeys to carbohydrates and suggest that previous negative results were due to the hyperosmotic nature of the glucose solutions.",
keywords = "CCK(A), Devazepide, Gastric emptying, Rhesus monkeys",
author = "Moran, {Timothy H.} and Field, {Douglas G.} and Susan Knipp and Carrigan, {Timothy S.} and Schwartz, {Gary J.}",
year = "1997",
doi = "10.1016/S0196-9781(97)00062-4",
language = "English (US)",
volume = "18",
pages = "547--550",
journal = "Peptides",
issn = "0196-9781",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Endogenous CCK in the control of gastric emptying of glucose and maltose

AU - Moran, Timothy H.

AU - Field, Douglas G.

AU - Knipp, Susan

AU - Carrigan, Timothy S.

AU - Schwartz, Gary J.

PY - 1997

Y1 - 1997

N2 - A role for endogenous cholecystokinin (CCK) in the control of gastric emptying of liquid glucose and maltose test meals in rhesus monkeys was assessed. Intragastric administration of a dose range (10-100 μg/kg) of the CCK(A) receptor antagonist devazepide produced a dose dependent acceleration of the emptying of 100 ml 300 mOsm test meals of glucose and maltose but had no effect on the emptying of a hyperosmotic (750 mOsm) NaCl solution. At the 100 μg/kg dose, the emptying of glucose and maltose meals were as rapid as the emptying of physiological NaCl. These data expand the demonstrated role of endogenous CCK in the slowing of gastric emptying of nutrients in rhesus monkeys to carbohydrates and suggest that previous negative results were due to the hyperosmotic nature of the glucose solutions.

AB - A role for endogenous cholecystokinin (CCK) in the control of gastric emptying of liquid glucose and maltose test meals in rhesus monkeys was assessed. Intragastric administration of a dose range (10-100 μg/kg) of the CCK(A) receptor antagonist devazepide produced a dose dependent acceleration of the emptying of 100 ml 300 mOsm test meals of glucose and maltose but had no effect on the emptying of a hyperosmotic (750 mOsm) NaCl solution. At the 100 μg/kg dose, the emptying of glucose and maltose meals were as rapid as the emptying of physiological NaCl. These data expand the demonstrated role of endogenous CCK in the slowing of gastric emptying of nutrients in rhesus monkeys to carbohydrates and suggest that previous negative results were due to the hyperosmotic nature of the glucose solutions.

KW - CCK(A)

KW - Devazepide

KW - Gastric emptying

KW - Rhesus monkeys

UR - http://www.scopus.com/inward/record.url?scp=0030992231&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030992231&partnerID=8YFLogxK

U2 - 10.1016/S0196-9781(97)00062-4

DO - 10.1016/S0196-9781(97)00062-4

M3 - Article

C2 - 9210174

AN - SCOPUS:0030992231

VL - 18

SP - 547

EP - 550

JO - Peptides

JF - Peptides

SN - 0196-9781

IS - 4

ER -