Endocytic pathways involved in filovirus entry: Advances, implications and future directions

Suchita Bhattacharyya, Nirupama Mulherkar, Kartik Chandran

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Detailed knowledge of the host-virus interactions that accompany filovirus entry into cells is expected to identify determinants of viral virulence and host range, and to yield targets for the development of antiviral therapeutics. While it is generally agreed that filovirus entry into the host cytoplasm requires viral internalization into acidic endosomal compartments and proteolytic cleavage of the envelope glycoprotein by endo/lysosomal cysteine proteases, our understanding of the specific endocytic pathways co-opted by filoviruses remains limited. This review addresses the current knowledge on cellular endocytic pathways implicated in filovirus entry, highlights the consensus as well as controversies, and discusses important remaining questions.

Original languageEnglish (US)
Pages (from-to)3647-3664
Number of pages18
JournalViruses
Volume4
Issue number12
DOIs
StatePublished - Dec 1 2012

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Keywords

  • Caveolae-mediated endocytosis
  • Clathrin-mediated endocytosis
  • Endocytic pathways
  • Endocytosis
  • Filoviruses
  • Macropinocytosis
  • Viral entry
  • Viral internalization

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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