Endocrine late-effects of childhood cancer and its treatments

Wassim Chemaitilly, Laurie E. Cohen

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations

Abstract

Endocrine complications are frequently observed in childhood cancer survivors (CCS). One of two CCS will experience at least one endocrine complication during the course of his/her lifespan, most commonly as a late-effect of cancer treatments, especially radiotherapy and alkylating agent chemotherapy. Endocrine late-effects include impairments of the hypothalamus/pituitary, thyroid and gonads, as well as decreased bone mineral density and metabolic derangements leading to obesity and/or diabetes mellitus. A systematic approach where CCS are screened for endocrine late-effects based on their cancer history and treatment exposures may improve health outcomes by allowing the early diagnosis and treatment of these complications.

Original languageEnglish (US)
Pages (from-to)R183-R203
JournalEuropean Journal of Endocrinology
Volume176
Issue number4
DOIs
StatePublished - Apr 2017
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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