Endocrine Function in Children With Human Immunodeficiency Virus Infection

Lisa J. Schwartz, Yolaine St Louis, Richard Wu, Andrew Wiznia, Arye Rubinstein, Paul Saenger

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

We sought to determine if failure to thrive in pediatric patients with the human immunodeficiency virus could be explained based on endocrine dysfunction. Fourteen human immunodeficiency virus—infected pediatric patients, all of whom had adequate nutritional status, underwent endocrine evaluation. Growth hormone and cortisol responses to glucagon stimulation were adequate. Despite this, eight of the 12 subjects had low somatomedin C levels. Although all patients were clinically and biochemically euthyroid, 36% (5/14) demonstrated elevated baseline and peak thyrotropin levels in response to thyroid releasing hormone, suggesting a state of compensated hypothyroidism. Although the importance of these findings is unclear, it is possible that subtle alterations of thyroid regulation may contribute to failure to thrive in some pediatric patients infected with human immunodeficiency virus and may represent a potentially correctable defect.

Original languageEnglish (US)
Pages (from-to)330-333
Number of pages4
JournalAmerican Journal of Diseases of Children
Volume145
Issue number3
DOIs
StatePublished - 1991

Fingerprint

Virus Diseases
HIV
Failure to Thrive
Pediatrics
Thyrotropin
Hypothyroidism
Glucagon
Nutritional Status
Insulin-Like Growth Factor I
Thyroid Hormones
Growth Hormone
Hydrocortisone
Thyroid Gland

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Endocrine Function in Children With Human Immunodeficiency Virus Infection. / Schwartz, Lisa J.; St Louis, Yolaine; Wu, Richard; Wiznia, Andrew; Rubinstein, Arye; Saenger, Paul.

In: American Journal of Diseases of Children, Vol. 145, No. 3, 1991, p. 330-333.

Research output: Contribution to journalArticle

Schwartz, Lisa J. ; St Louis, Yolaine ; Wu, Richard ; Wiznia, Andrew ; Rubinstein, Arye ; Saenger, Paul. / Endocrine Function in Children With Human Immunodeficiency Virus Infection. In: American Journal of Diseases of Children. 1991 ; Vol. 145, No. 3. pp. 330-333.
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