TY - JOUR
T1 - Endocrine Function in Children With Human Immunodeficiency Virus Infection
AU - Schwartz, Lisa J.
AU - St Louis, Yolaine
AU - Wu, Richard
AU - Wiznia, Andrew
AU - Rubinstein, Arye
AU - Saenger, Paul
PY - 1991/3
Y1 - 1991/3
N2 - We sought to determine if failure to thrive in pediatric patients with the human immunodeficiency virus could be explained based on endocrine dysfunction. Fourteen human immunodeficiency virus—infected pediatric patients, all of whom had adequate nutritional status, underwent endocrine evaluation. Growth hormone and cortisol responses to glucagon stimulation were adequate. Despite this, eight of the 12 subjects had low somatomedin C levels. Although all patients were clinically and biochemically euthyroid, 36% (5/14) demonstrated elevated baseline and peak thyrotropin levels in response to thyroid releasing hormone, suggesting a state of compensated hypothyroidism. Although the importance of these findings is unclear, it is possible that subtle alterations of thyroid regulation may contribute to failure to thrive in some pediatric patients infected with human immunodeficiency virus and may represent a potentially correctable defect.
AB - We sought to determine if failure to thrive in pediatric patients with the human immunodeficiency virus could be explained based on endocrine dysfunction. Fourteen human immunodeficiency virus—infected pediatric patients, all of whom had adequate nutritional status, underwent endocrine evaluation. Growth hormone and cortisol responses to glucagon stimulation were adequate. Despite this, eight of the 12 subjects had low somatomedin C levels. Although all patients were clinically and biochemically euthyroid, 36% (5/14) demonstrated elevated baseline and peak thyrotropin levels in response to thyroid releasing hormone, suggesting a state of compensated hypothyroidism. Although the importance of these findings is unclear, it is possible that subtle alterations of thyroid regulation may contribute to failure to thrive in some pediatric patients infected with human immunodeficiency virus and may represent a potentially correctable defect.
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U2 - 10.1001/archpedi.1991.02160030100030
DO - 10.1001/archpedi.1991.02160030100030
M3 - Article
C2 - 2003485
AN - SCOPUS:0025968402
SN - 0002-922X
VL - 145
SP - 330
EP - 333
JO - American Journal of Diseases of Children
JF - American Journal of Diseases of Children
IS - 3
ER -