TY - JOUR
T1 - Endocervical adenocarcinoma in situ with ovarian metastases
T2 - A unique variant with potential for long-term survival
AU - Chang, Martin C.
AU - Nevadunsky, Nicole S.
AU - Viswanathan, Akila N.
AU - Crum, Christopher P.
AU - Feltmate, Colleen M.
N1 - Funding Information:
This study was financed by a grant for clinical research from the Spanish Society of Cardiology, Instituto de Salud Carlos III – European Regional Development Fund (Cardiovascular Research Network RD12/0042; PI09/90506), AGAUR (2009 SGR 1195).
PY - 2010/1
Y1 - 2010/1
N2 - Adenocarcinoma in situ (AIS) of the endocervix is typically confined to the cervix, but may be extensive. We report 2 cases of extensive AIS-one with intraendometrial spread-that recurred after cone biopsy and were associated with ovarian metastases. In both cases, primary and metastatic tumors were positive for human papillomavirus 16. Both patients are currently disease-free and one has had no recurrence after a follow-up period of 145 months. Extensive, recurring AIS is a rare variant that may be unique for its risk of coincident ovarian involvement. However, ovarian spread, albeit rare, does not invariably result in an adverse outcome.
AB - Adenocarcinoma in situ (AIS) of the endocervix is typically confined to the cervix, but may be extensive. We report 2 cases of extensive AIS-one with intraendometrial spread-that recurred after cone biopsy and were associated with ovarian metastases. In both cases, primary and metastatic tumors were positive for human papillomavirus 16. Both patients are currently disease-free and one has had no recurrence after a follow-up period of 145 months. Extensive, recurring AIS is a rare variant that may be unique for its risk of coincident ovarian involvement. However, ovarian spread, albeit rare, does not invariably result in an adverse outcome.
KW - Adenocarcinoma in situ
KW - Cervix neoplasms
KW - HPV
KW - Ovarian neoplasia
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UR - http://www.scopus.com/inward/citedby.url?scp=76149086829&partnerID=8YFLogxK
U2 - 10.1097/PGP.0b013e3181acefbf
DO - 10.1097/PGP.0b013e3181acefbf
M3 - Article
C2 - 19952931
AN - SCOPUS:76149086829
SN - 0277-1691
VL - 29
SP - 88
EP - 92
JO - International Journal of Gynecological Pathology
JF - International Journal of Gynecological Pathology
IS - 1
ER -
