Endocervical adenocarcinoma in situ with ovarian metastases: A unique variant with potential for long-term survival

Martin C. Chang, Nicole S. Nevadunsky, Akila N. Viswanathan, Christopher P. Crum, Colleen M. Feltmate

Research output: Contribution to journalArticle

25 Scopus citations


Adenocarcinoma in situ (AIS) of the endocervix is typically confined to the cervix, but may be extensive. We report 2 cases of extensive AIS-one with intraendometrial spread-that recurred after cone biopsy and were associated with ovarian metastases. In both cases, primary and metastatic tumors were positive for human papillomavirus 16. Both patients are currently disease-free and one has had no recurrence after a follow-up period of 145 months. Extensive, recurring AIS is a rare variant that may be unique for its risk of coincident ovarian involvement. However, ovarian spread, albeit rare, does not invariably result in an adverse outcome.

Original languageEnglish (US)
Pages (from-to)88-92
Number of pages5
JournalInternational Journal of Gynecological Pathology
Issue number1
Publication statusPublished - Jan 1 2010
Externally publishedYes



  • Adenocarcinoma in situ
  • Cervix neoplasms
  • HPV
  • Ovarian neoplasia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology

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