Abstract
Shigeta et al. found that a subset of macrophages in the heart valves originates locally from the fetal endocardium. This local type of macrophages is more phagocytic than other macrophages and critical for the valve remodeling during cardiogenesis.
Original language | English (US) |
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Pages (from-to) | 617-630.e3 |
Journal | Developmental cell |
Volume | 48 |
Issue number | 5 |
DOIs | |
State | Published - Mar 11 2019 |
Keywords
- cardiac tissue macrophage
- cardiogenesis
- congenital heart disease
- hematopoiesis
- hemogenic endocardium
- multipotent cardiac progenitor cells
- tissue macrophages
- valve disease
- valve remodeling
- valvulogenesis
ASJC Scopus subject areas
- Molecular Biology
- General Biochemistry, Genetics and Molecular Biology
- Developmental Biology
- Cell Biology