Endocannabinoid signaling and long-term synaptic plasticity

Boris D. Heifets, Pablo E. Castillo

Research output: Contribution to journalArticle

277 Citations (Scopus)

Abstract

Endocannabinoids (eCBs) are key activity-dependent signals regulating synaptic transmission throughout the central nervous system. Accordingly, eCBs are involved in neural functions ranging from feeding homeostasis to cognition. There is great interest in understanding how exogenous (e.g., cannabis) and endogenous cannabinoids affect behavior. Because behavioral adaptations are widely considered to rely on changes in synaptic strength, the prevalence of eCB-mediated longterm depression (eCB-LTD) at synapses throughout the brain merits close attention. The induction and expression of eCB-LTD, although remarkably similar at various synapses, are controlled by an array of regulatory influences that we are just beginning to uncover. This complexity endows eCB-LTD with important computational properties, such as coincidence detection and input specificity, critical for higher CNS functions like learning and memory. In this article, we review the major molecular and cellular mechanisms underlying eCB-LTD, as well as the potential physiological relevance of this widespread form of synaptic plasticity.

Original languageEnglish (US)
Pages (from-to)283-306
Number of pages24
JournalAnnual Review of Physiology
Volume71
DOIs
StatePublished - Mar 2009

Fingerprint

Endocannabinoids
Neuronal Plasticity
Depression
Synapses
Cannabinoids
Cannabis
Synaptic Transmission
Cognition
Homeostasis
Central Nervous System
Learning
Brain

Keywords

  • Cannabinoid
  • CB1
  • Drug addiction
  • Learning
  • LTD
  • LTP
  • Parkinson's disease
  • STDP
  • Synaptic transmission

ASJC Scopus subject areas

  • Physiology

Cite this

Endocannabinoid signaling and long-term synaptic plasticity. / Heifets, Boris D.; Castillo, Pablo E.

In: Annual Review of Physiology, Vol. 71, 03.2009, p. 283-306.

Research output: Contribution to journalArticle

@article{1093d6c155ef41d1a815ef3bc30f6eb1,
title = "Endocannabinoid signaling and long-term synaptic plasticity",
abstract = "Endocannabinoids (eCBs) are key activity-dependent signals regulating synaptic transmission throughout the central nervous system. Accordingly, eCBs are involved in neural functions ranging from feeding homeostasis to cognition. There is great interest in understanding how exogenous (e.g., cannabis) and endogenous cannabinoids affect behavior. Because behavioral adaptations are widely considered to rely on changes in synaptic strength, the prevalence of eCB-mediated longterm depression (eCB-LTD) at synapses throughout the brain merits close attention. The induction and expression of eCB-LTD, although remarkably similar at various synapses, are controlled by an array of regulatory influences that we are just beginning to uncover. This complexity endows eCB-LTD with important computational properties, such as coincidence detection and input specificity, critical for higher CNS functions like learning and memory. In this article, we review the major molecular and cellular mechanisms underlying eCB-LTD, as well as the potential physiological relevance of this widespread form of synaptic plasticity.",
keywords = "Cannabinoid, CB1, Drug addiction, Learning, LTD, LTP, Parkinson's disease, STDP, Synaptic transmission",
author = "Heifets, {Boris D.} and Castillo, {Pablo E.}",
year = "2009",
month = "3",
doi = "10.1146/annurev.physiol.010908.163149",
language = "English (US)",
volume = "71",
pages = "283--306",
journal = "Annual Review of Physiology",
issn = "0066-4278",
publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - Endocannabinoid signaling and long-term synaptic plasticity

AU - Heifets, Boris D.

AU - Castillo, Pablo E.

PY - 2009/3

Y1 - 2009/3

N2 - Endocannabinoids (eCBs) are key activity-dependent signals regulating synaptic transmission throughout the central nervous system. Accordingly, eCBs are involved in neural functions ranging from feeding homeostasis to cognition. There is great interest in understanding how exogenous (e.g., cannabis) and endogenous cannabinoids affect behavior. Because behavioral adaptations are widely considered to rely on changes in synaptic strength, the prevalence of eCB-mediated longterm depression (eCB-LTD) at synapses throughout the brain merits close attention. The induction and expression of eCB-LTD, although remarkably similar at various synapses, are controlled by an array of regulatory influences that we are just beginning to uncover. This complexity endows eCB-LTD with important computational properties, such as coincidence detection and input specificity, critical for higher CNS functions like learning and memory. In this article, we review the major molecular and cellular mechanisms underlying eCB-LTD, as well as the potential physiological relevance of this widespread form of synaptic plasticity.

AB - Endocannabinoids (eCBs) are key activity-dependent signals regulating synaptic transmission throughout the central nervous system. Accordingly, eCBs are involved in neural functions ranging from feeding homeostasis to cognition. There is great interest in understanding how exogenous (e.g., cannabis) and endogenous cannabinoids affect behavior. Because behavioral adaptations are widely considered to rely on changes in synaptic strength, the prevalence of eCB-mediated longterm depression (eCB-LTD) at synapses throughout the brain merits close attention. The induction and expression of eCB-LTD, although remarkably similar at various synapses, are controlled by an array of regulatory influences that we are just beginning to uncover. This complexity endows eCB-LTD with important computational properties, such as coincidence detection and input specificity, critical for higher CNS functions like learning and memory. In this article, we review the major molecular and cellular mechanisms underlying eCB-LTD, as well as the potential physiological relevance of this widespread form of synaptic plasticity.

KW - Cannabinoid

KW - CB1

KW - Drug addiction

KW - Learning

KW - LTD

KW - LTP

KW - Parkinson's disease

KW - STDP

KW - Synaptic transmission

UR - http://www.scopus.com/inward/record.url?scp=67651173255&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67651173255&partnerID=8YFLogxK

U2 - 10.1146/annurev.physiol.010908.163149

DO - 10.1146/annurev.physiol.010908.163149

M3 - Article

VL - 71

SP - 283

EP - 306

JO - Annual Review of Physiology

JF - Annual Review of Physiology

SN - 0066-4278

ER -