Endocannabinoid-mediated synaptic plasticity in the CNS

Vivien Chevaleyre, Kanji A. Takahashi, Pablo E. Castillo

Research output: Contribution to journalArticle

546 Citations (Scopus)

Abstract

Changes in synaptic efficacy are thought to be crucial to experience-dependent modifications of neural function. The diversity of mechanisms underlying these changes is far greater than previously expected. In the last five years, a new class of use-dependent synaptic plasticity that requires retrograde signaling by endocannabinoids (eCB) and presynaptic CB1 receptor activation has been identified in several brain structures. eCB-mediated plasticity encompasses many forms of transient and long-lasting synaptic depression and is found at both excitatory and inhibitory synapses. In addition, eCBs can modify the inducibility of non-eCB-mediated forms of plasticity. Thus, the eCB system is emerging as a major player in synaptic plasticity. Given the wide distribution of CB1 receptors in the CNS, the list of brain structures and synapses expressing eCB-mediated plasticity is likely to expand.

Original languageEnglish (US)
Pages (from-to)37-76
Number of pages40
JournalAnnual Review of Neuroscience
Volume29
DOIs
StatePublished - 2006

Fingerprint

Endocannabinoids
Neuronal Plasticity
Cannabinoid Receptor CB1
Synapses
Presynaptic Receptors
Brain

Keywords

  • Cannabinoid
  • CB1
  • LTD
  • LTP
  • Synaptic transmission

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Endocannabinoid-mediated synaptic plasticity in the CNS. / Chevaleyre, Vivien; Takahashi, Kanji A.; Castillo, Pablo E.

In: Annual Review of Neuroscience, Vol. 29, 2006, p. 37-76.

Research output: Contribution to journalArticle

Chevaleyre, Vivien ; Takahashi, Kanji A. ; Castillo, Pablo E. / Endocannabinoid-mediated synaptic plasticity in the CNS. In: Annual Review of Neuroscience. 2006 ; Vol. 29. pp. 37-76.
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