Endocannabinoid-mediated long-term depression in the avian midbrain expressed presynaptically and postsynaptically

Mario Alexander Penzo, Jose L. Pena

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Here, we examined long-term synaptic plasticity in the avian auditory midbrain, a region involved in experience-dependent learning. We found that coactivation of N-methyl-D-aspartate receptors (NMDAR) and type 1 cannabinoid receptors (CB1R) induces long-term depression (LTD) at the synapse between the central shell and the external portion of the inferior colliculus of the chicken. Although endocannabinoids are commonly thought of as presynaptic modulators, recent reports have suggested that they can also modulate the postsynaptic site. In the avian midbrain, we found that LTD is mediated by both presynaptic and postsynaptic changes. The presynaptic mechanism consists of a decrease in neurotransmitter release, whereas a depression of NMDAR-mediated current takes place on the postsynaptic side. Both the presynaptic and the postsynaptic effects depend on CB1R activation. The reduction of postsynaptic NMDAR currents represents a novel role of endocannabinoids in synaptic modulation.

Original languageEnglish (US)
Pages (from-to)4131-4139
Number of pages9
JournalJournal of Neuroscience
Volume29
Issue number13
DOIs
StatePublished - Apr 1 2009

Fingerprint

Endocannabinoids
Mesencephalon
N-Methyl-D-Aspartate Receptors
Depression
Inferior Colliculi
Cannabinoid Receptors
Neuronal Plasticity
Synapses
Neurotransmitter Agents
Chickens
Learning

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Endocannabinoid-mediated long-term depression in the avian midbrain expressed presynaptically and postsynaptically. / Penzo, Mario Alexander; Pena, Jose L.

In: Journal of Neuroscience, Vol. 29, No. 13, 01.04.2009, p. 4131-4139.

Research output: Contribution to journalArticle

@article{9f5780a9d1dd466bb44d2bd69a8ac80f,
title = "Endocannabinoid-mediated long-term depression in the avian midbrain expressed presynaptically and postsynaptically",
abstract = "Here, we examined long-term synaptic plasticity in the avian auditory midbrain, a region involved in experience-dependent learning. We found that coactivation of N-methyl-D-aspartate receptors (NMDAR) and type 1 cannabinoid receptors (CB1R) induces long-term depression (LTD) at the synapse between the central shell and the external portion of the inferior colliculus of the chicken. Although endocannabinoids are commonly thought of as presynaptic modulators, recent reports have suggested that they can also modulate the postsynaptic site. In the avian midbrain, we found that LTD is mediated by both presynaptic and postsynaptic changes. The presynaptic mechanism consists of a decrease in neurotransmitter release, whereas a depression of NMDAR-mediated current takes place on the postsynaptic side. Both the presynaptic and the postsynaptic effects depend on CB1R activation. The reduction of postsynaptic NMDAR currents represents a novel role of endocannabinoids in synaptic modulation.",
author = "Penzo, {Mario Alexander} and Pena, {Jose L.}",
year = "2009",
month = "4",
day = "1",
doi = "10.1523/JNEUROSCI.5466-08.2009",
language = "English (US)",
volume = "29",
pages = "4131--4139",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "13",

}

TY - JOUR

T1 - Endocannabinoid-mediated long-term depression in the avian midbrain expressed presynaptically and postsynaptically

AU - Penzo, Mario Alexander

AU - Pena, Jose L.

PY - 2009/4/1

Y1 - 2009/4/1

N2 - Here, we examined long-term synaptic plasticity in the avian auditory midbrain, a region involved in experience-dependent learning. We found that coactivation of N-methyl-D-aspartate receptors (NMDAR) and type 1 cannabinoid receptors (CB1R) induces long-term depression (LTD) at the synapse between the central shell and the external portion of the inferior colliculus of the chicken. Although endocannabinoids are commonly thought of as presynaptic modulators, recent reports have suggested that they can also modulate the postsynaptic site. In the avian midbrain, we found that LTD is mediated by both presynaptic and postsynaptic changes. The presynaptic mechanism consists of a decrease in neurotransmitter release, whereas a depression of NMDAR-mediated current takes place on the postsynaptic side. Both the presynaptic and the postsynaptic effects depend on CB1R activation. The reduction of postsynaptic NMDAR currents represents a novel role of endocannabinoids in synaptic modulation.

AB - Here, we examined long-term synaptic plasticity in the avian auditory midbrain, a region involved in experience-dependent learning. We found that coactivation of N-methyl-D-aspartate receptors (NMDAR) and type 1 cannabinoid receptors (CB1R) induces long-term depression (LTD) at the synapse between the central shell and the external portion of the inferior colliculus of the chicken. Although endocannabinoids are commonly thought of as presynaptic modulators, recent reports have suggested that they can also modulate the postsynaptic site. In the avian midbrain, we found that LTD is mediated by both presynaptic and postsynaptic changes. The presynaptic mechanism consists of a decrease in neurotransmitter release, whereas a depression of NMDAR-mediated current takes place on the postsynaptic side. Both the presynaptic and the postsynaptic effects depend on CB1R activation. The reduction of postsynaptic NMDAR currents represents a novel role of endocannabinoids in synaptic modulation.

UR - http://www.scopus.com/inward/record.url?scp=65249155017&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65249155017&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.5466-08.2009

DO - 10.1523/JNEUROSCI.5466-08.2009

M3 - Article

VL - 29

SP - 4131

EP - 4139

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 13

ER -