End-stage renal disease predicts complications in pacemaker and ICD implants

Christine Tompkins, Rhondalyn McLean, Alan Cheng, Jeffrey A. Brinker, Joseph E. Marine, Saman Nazarian, David D. Spragg, Sunil Sinha, Henry Halperin, Gordon F. Tomaselli, Ronald D. Berger, Hugh Calkins, Charles A. Henrikson

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

End-Stage Renal Disease Predicts Complications in Pacemaker and ICD Implants. Introduction: Patients with chronic kidney disease (CKD) have increased morbidity following invasive procedures. We hypothesized that patients with CKD have higher complication rates following device implantation than patients with normal renal function. Methods: We reviewed the medical records of patients undergoing ICD or pacemaker implantation from August 2004 to August 2007. The estimated glomerular filtration rate (GFR) was calculated using the Cockroft-Gault equation. Those with GFR ≥ 90 cc/min served as controls. The remainder was grouped according to American Kidney Foundation stages of CKD. Bleeding complications were defined as need for pocket exploration or blood transfusion; cardiac tamponade; or hematoma requiring pressure dressing, change in medications or prolonged hospitalization. Infection was defined as infection of the pocket or lead system, or development of bacteremia/sepsis within 60 days. Results: There were 82 bleeding complications (5.7%) and 7 infections (0.5%) temporally related to device implantation in 1,440 patients. End-stage renal disease (ESRD), defined as GFR < 15 mL/min or need for dialysis, was identified in 32 patients. Infection rates were significantly higher in patients with ESRD versus controls (12.5% vs 0.2%; P < 0.0001). A significant increase in bleeding complications was observed in ESRD versus controls (21.9% vs 3.2%, respectively; P<0.0001). Bleeding complications were considerably greater than controls in moderate (GFR 30-59 mL/min) and severe (GFR 15-29 mL/min) CKD (7.4% and 9.8% vs 3.2%, respectively; P < 0.005). Conclusion: ESRD markedly increases bleeding and device-related infections. The risk of both complications parallels the severity of CKD. Further research is needed to reduce adverse outcomes in this high-risk population.

Original languageEnglish (US)
Pages (from-to)1099-1104
Number of pages6
JournalJournal of Cardiovascular Electrophysiology
Volume22
Issue number10
DOIs
StatePublished - Oct 1 2011
Externally publishedYes

Fingerprint

Chronic Kidney Failure
Glomerular Filtration Rate
Chronic Renal Insufficiency
Hemorrhage
Infection
Equipment and Supplies
Kidney
Cardiac Tamponade
Bandages
Bacteremia
Blood Transfusion
Hematoma
Medical Records
Dialysis
Sepsis
Hospitalization
Morbidity
Pressure
Research
Population

Keywords

  • chronic kidney disease
  • heart failure
  • implantable cardioverter defibrillator
  • infection
  • pacemaker

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Tompkins, C., McLean, R., Cheng, A., Brinker, J. A., Marine, J. E., Nazarian, S., ... Henrikson, C. A. (2011). End-stage renal disease predicts complications in pacemaker and ICD implants. Journal of Cardiovascular Electrophysiology, 22(10), 1099-1104. https://doi.org/10.1111/j.1540-8167.2011.02066.x

End-stage renal disease predicts complications in pacemaker and ICD implants. / Tompkins, Christine; McLean, Rhondalyn; Cheng, Alan; Brinker, Jeffrey A.; Marine, Joseph E.; Nazarian, Saman; Spragg, David D.; Sinha, Sunil; Halperin, Henry; Tomaselli, Gordon F.; Berger, Ronald D.; Calkins, Hugh; Henrikson, Charles A.

In: Journal of Cardiovascular Electrophysiology, Vol. 22, No. 10, 01.10.2011, p. 1099-1104.

Research output: Contribution to journalArticle

Tompkins, C, McLean, R, Cheng, A, Brinker, JA, Marine, JE, Nazarian, S, Spragg, DD, Sinha, S, Halperin, H, Tomaselli, GF, Berger, RD, Calkins, H & Henrikson, CA 2011, 'End-stage renal disease predicts complications in pacemaker and ICD implants', Journal of Cardiovascular Electrophysiology, vol. 22, no. 10, pp. 1099-1104. https://doi.org/10.1111/j.1540-8167.2011.02066.x
Tompkins, Christine ; McLean, Rhondalyn ; Cheng, Alan ; Brinker, Jeffrey A. ; Marine, Joseph E. ; Nazarian, Saman ; Spragg, David D. ; Sinha, Sunil ; Halperin, Henry ; Tomaselli, Gordon F. ; Berger, Ronald D. ; Calkins, Hugh ; Henrikson, Charles A. / End-stage renal disease predicts complications in pacemaker and ICD implants. In: Journal of Cardiovascular Electrophysiology. 2011 ; Vol. 22, No. 10. pp. 1099-1104.
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abstract = "End-Stage Renal Disease Predicts Complications in Pacemaker and ICD Implants. Introduction: Patients with chronic kidney disease (CKD) have increased morbidity following invasive procedures. We hypothesized that patients with CKD have higher complication rates following device implantation than patients with normal renal function. Methods: We reviewed the medical records of patients undergoing ICD or pacemaker implantation from August 2004 to August 2007. The estimated glomerular filtration rate (GFR) was calculated using the Cockroft-Gault equation. Those with GFR ≥ 90 cc/min served as controls. The remainder was grouped according to American Kidney Foundation stages of CKD. Bleeding complications were defined as need for pocket exploration or blood transfusion; cardiac tamponade; or hematoma requiring pressure dressing, change in medications or prolonged hospitalization. Infection was defined as infection of the pocket or lead system, or development of bacteremia/sepsis within 60 days. Results: There were 82 bleeding complications (5.7{\%}) and 7 infections (0.5{\%}) temporally related to device implantation in 1,440 patients. End-stage renal disease (ESRD), defined as GFR < 15 mL/min or need for dialysis, was identified in 32 patients. Infection rates were significantly higher in patients with ESRD versus controls (12.5{\%} vs 0.2{\%}; P < 0.0001). A significant increase in bleeding complications was observed in ESRD versus controls (21.9{\%} vs 3.2{\%}, respectively; P<0.0001). Bleeding complications were considerably greater than controls in moderate (GFR 30-59 mL/min) and severe (GFR 15-29 mL/min) CKD (7.4{\%} and 9.8{\%} vs 3.2{\%}, respectively; P < 0.005). Conclusion: ESRD markedly increases bleeding and device-related infections. The risk of both complications parallels the severity of CKD. Further research is needed to reduce adverse outcomes in this high-risk population.",
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