End-stage renal disease among HIV-infected adults in North America

Alison G. Abraham, Keri N. Althoff, Yuezhou Jing, Michelle M. Estrella, Mari M. Kitahata, C. William Wester, Ronald J. Bosch, Heidi Crane, Joseph Eron, M. John Gill, Michael A. Horberg, Amy C. Justice, Marina Klein, Angel M. Mayor, Richard D. Moore, Frank J. Palella, Chirag R. Parikh, Michael J. Silverberg, Elizabeth T. Golub, Lisa P. Jacobson & 53 others Sonia Napravnik, Gregory M. Lucas, Gregory D. Kirk, Constance A. Benson, Ann C. Collier, Stephen Boswell, Chris Grasso, Ken Mayer, Robert S. Hogg, Richard Harrigan, Julio Montaner, Angela Cescon, John T. Brooks, Kate Buchacz, Kelly A. Gebo, Benigno Rodriguez, Jennifer E. Thorne, James J. Goedert, Marina B. Klein, Sean B. Rourke, Ann Burchell, Anita R. Rachlis, Robert F. Hunter-Mellado, Steven G. Deeks, Jeffrey N. Martin, Michael S. Saag, Michael J. Mugavero, James Willig, Joseph J. Eron, Heidi M. Crane, Robert Dubrow, David Fiellin, Timothy R. Sterling, David Haas, Kathryn Anastos, Megan Turner, Stephen J. Gange, Kathryn Anastos, Rosemary G. McKaig, Aimee M. Freeman, Carol Lent, Stephen E. Van Rompaey, Eric Webster, Liz Morton, Brenda Simon, David B. Hanna, Jinbing Zhang, Jerry Jing, Shari Modur, David B. Hanna, Peter Rebeiro, Cherise Wong, Adell Mendes

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Background. Human immunodeficiency virus (HIV)-infected adults, particularly those of black race, are at high-risk for end-stage renal disease (ESRD), but contributing factors are evolving. We hypothesized that improvements in HIV treatment have led to declines in risk of ESRD, particularly among HIV-infected blacks. Methods. Using data from the North American AIDS Cohort Collaboration for Research and Design from January 2000 to December 2009, we validated 286 incident ESRD cases using abstracted medical evidence of dialysis (lasting >6 months) or renal transplant. A total of 38 354 HIV-infected adults aged 18-80 years contributed 159 825 person-years (PYs). Age- and sex-standardized incidence ratios (SIRs) were estimated by race. Poisson regression was used to identify predictors of ESRD. Results. HIV-infected ESRD cases were more likely to be of black race, have diabetes mellitus or hypertension, inject drugs, and/or have a prior AIDS-defining illness. The overall SIR was 3.2 (95% confidence interval [CI], 2.8- 3.6) but was significantly higher among black patients (4.5 [95% CI, 3.9-5.2]). ESRD incidence declined from 532 to 303 per 100 000 PYs and 138 to 34 per 100 000 PYs over the time period for blacks and nonblacks, respectively, coincident with notable increases in both the prevalence of viral suppression and the prevalence of ESRD risk factors including diabetes mellitus, hypertension, and hepatitis C virus coinfection. Conclusions. The risk of ESRD remains high among HIV-infected individuals in care but is declining with improvements in virologic suppression. HIV-infected black persons continue to comprise the majority of cases, as a result of higher viral loads, comorbidities, and genetic susceptibility.

Original languageEnglish (US)
Pages (from-to)941-949
Number of pages9
JournalClinical Infectious Diseases
Volume60
Issue number6
DOIs
StatePublished - 2015
Externally publishedYes

Fingerprint

North America
Chronic Kidney Failure
HIV
Incidence
Diabetes Mellitus
Acquired Immunodeficiency Syndrome
Confidence Intervals
Hypertension
Genetic Predisposition to Disease
Viral Load
Coinfection
Hepacivirus
Comorbidity
Dialysis
Research Design
Transplants
Kidney
Pharmaceutical Preparations

Keywords

  • Chronic kidney disease (CKD)
  • End-stage renal disease (ESRD)
  • Glomerular filtration rate (GFR)
  • HIV infection/AIDS
  • HIV/AIDS

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)

Cite this

Abraham, A. G., Althoff, K. N., Jing, Y., Estrella, M. M., Kitahata, M. M., Wester, C. W., ... Mendes, A. (2015). End-stage renal disease among HIV-infected adults in North America. Clinical Infectious Diseases, 60(6), 941-949. https://doi.org/10.1093/cid/ciu919

End-stage renal disease among HIV-infected adults in North America. / Abraham, Alison G.; Althoff, Keri N.; Jing, Yuezhou; Estrella, Michelle M.; Kitahata, Mari M.; Wester, C. William; Bosch, Ronald J.; Crane, Heidi; Eron, Joseph; Gill, M. John; Horberg, Michael A.; Justice, Amy C.; Klein, Marina; Mayor, Angel M.; Moore, Richard D.; Palella, Frank J.; Parikh, Chirag R.; Silverberg, Michael J.; Golub, Elizabeth T.; Jacobson, Lisa P.; Napravnik, Sonia; Lucas, Gregory M.; Kirk, Gregory D.; Benson, Constance A.; Collier, Ann C.; Boswell, Stephen; Grasso, Chris; Mayer, Ken; Hogg, Robert S.; Harrigan, Richard; Montaner, Julio; Cescon, Angela; Brooks, John T.; Buchacz, Kate; Gebo, Kelly A.; Rodriguez, Benigno; Thorne, Jennifer E.; Goedert, James J.; Klein, Marina B.; Rourke, Sean B.; Burchell, Ann; Rachlis, Anita R.; Hunter-Mellado, Robert F.; Deeks, Steven G.; Martin, Jeffrey N.; Saag, Michael S.; Mugavero, Michael J.; Willig, James; Eron, Joseph J.; Crane, Heidi M.; Dubrow, Robert; Fiellin, David; Sterling, Timothy R.; Haas, David; Anastos, Kathryn; Turner, Megan; Gange, Stephen J.; Anastos, Kathryn; McKaig, Rosemary G.; Freeman, Aimee M.; Lent, Carol; Van Rompaey, Stephen E.; Webster, Eric; Morton, Liz; Simon, Brenda; Hanna, David B.; Zhang, Jinbing; Jing, Jerry; Modur, Shari; Hanna, David B.; Rebeiro, Peter; Wong, Cherise; Mendes, Adell.

In: Clinical Infectious Diseases, Vol. 60, No. 6, 2015, p. 941-949.

Research output: Contribution to journalArticle

Abraham, AG, Althoff, KN, Jing, Y, Estrella, MM, Kitahata, MM, Wester, CW, Bosch, RJ, Crane, H, Eron, J, Gill, MJ, Horberg, MA, Justice, AC, Klein, M, Mayor, AM, Moore, RD, Palella, FJ, Parikh, CR, Silverberg, MJ, Golub, ET, Jacobson, LP, Napravnik, S, Lucas, GM, Kirk, GD, Benson, CA, Collier, AC, Boswell, S, Grasso, C, Mayer, K, Hogg, RS, Harrigan, R, Montaner, J, Cescon, A, Brooks, JT, Buchacz, K, Gebo, KA, Rodriguez, B, Thorne, JE, Goedert, JJ, Klein, MB, Rourke, SB, Burchell, A, Rachlis, AR, Hunter-Mellado, RF, Deeks, SG, Martin, JN, Saag, MS, Mugavero, MJ, Willig, J, Eron, JJ, Crane, HM, Dubrow, R, Fiellin, D, Sterling, TR, Haas, D, Anastos, K, Turner, M, Gange, SJ, Anastos, K, McKaig, RG, Freeman, AM, Lent, C, Van Rompaey, SE, Webster, E, Morton, L, Simon, B, Hanna, DB, Zhang, J, Jing, J, Modur, S, Hanna, DB, Rebeiro, P, Wong, C & Mendes, A 2015, 'End-stage renal disease among HIV-infected adults in North America', Clinical Infectious Diseases, vol. 60, no. 6, pp. 941-949. https://doi.org/10.1093/cid/ciu919
Abraham AG, Althoff KN, Jing Y, Estrella MM, Kitahata MM, Wester CW et al. End-stage renal disease among HIV-infected adults in North America. Clinical Infectious Diseases. 2015;60(6):941-949. https://doi.org/10.1093/cid/ciu919
Abraham, Alison G. ; Althoff, Keri N. ; Jing, Yuezhou ; Estrella, Michelle M. ; Kitahata, Mari M. ; Wester, C. William ; Bosch, Ronald J. ; Crane, Heidi ; Eron, Joseph ; Gill, M. John ; Horberg, Michael A. ; Justice, Amy C. ; Klein, Marina ; Mayor, Angel M. ; Moore, Richard D. ; Palella, Frank J. ; Parikh, Chirag R. ; Silverberg, Michael J. ; Golub, Elizabeth T. ; Jacobson, Lisa P. ; Napravnik, Sonia ; Lucas, Gregory M. ; Kirk, Gregory D. ; Benson, Constance A. ; Collier, Ann C. ; Boswell, Stephen ; Grasso, Chris ; Mayer, Ken ; Hogg, Robert S. ; Harrigan, Richard ; Montaner, Julio ; Cescon, Angela ; Brooks, John T. ; Buchacz, Kate ; Gebo, Kelly A. ; Rodriguez, Benigno ; Thorne, Jennifer E. ; Goedert, James J. ; Klein, Marina B. ; Rourke, Sean B. ; Burchell, Ann ; Rachlis, Anita R. ; Hunter-Mellado, Robert F. ; Deeks, Steven G. ; Martin, Jeffrey N. ; Saag, Michael S. ; Mugavero, Michael J. ; Willig, James ; Eron, Joseph J. ; Crane, Heidi M. ; Dubrow, Robert ; Fiellin, David ; Sterling, Timothy R. ; Haas, David ; Anastos, Kathryn ; Turner, Megan ; Gange, Stephen J. ; Anastos, Kathryn ; McKaig, Rosemary G. ; Freeman, Aimee M. ; Lent, Carol ; Van Rompaey, Stephen E. ; Webster, Eric ; Morton, Liz ; Simon, Brenda ; Hanna, David B. ; Zhang, Jinbing ; Jing, Jerry ; Modur, Shari ; Hanna, David B. ; Rebeiro, Peter ; Wong, Cherise ; Mendes, Adell. / End-stage renal disease among HIV-infected adults in North America. In: Clinical Infectious Diseases. 2015 ; Vol. 60, No. 6. pp. 941-949.
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title = "End-stage renal disease among HIV-infected adults in North America",
abstract = "Background. Human immunodeficiency virus (HIV)-infected adults, particularly those of black race, are at high-risk for end-stage renal disease (ESRD), but contributing factors are evolving. We hypothesized that improvements in HIV treatment have led to declines in risk of ESRD, particularly among HIV-infected blacks. Methods. Using data from the North American AIDS Cohort Collaboration for Research and Design from January 2000 to December 2009, we validated 286 incident ESRD cases using abstracted medical evidence of dialysis (lasting >6 months) or renal transplant. A total of 38 354 HIV-infected adults aged 18-80 years contributed 159 825 person-years (PYs). Age- and sex-standardized incidence ratios (SIRs) were estimated by race. Poisson regression was used to identify predictors of ESRD. Results. HIV-infected ESRD cases were more likely to be of black race, have diabetes mellitus or hypertension, inject drugs, and/or have a prior AIDS-defining illness. The overall SIR was 3.2 (95{\%} confidence interval [CI], 2.8- 3.6) but was significantly higher among black patients (4.5 [95{\%} CI, 3.9-5.2]). ESRD incidence declined from 532 to 303 per 100 000 PYs and 138 to 34 per 100 000 PYs over the time period for blacks and nonblacks, respectively, coincident with notable increases in both the prevalence of viral suppression and the prevalence of ESRD risk factors including diabetes mellitus, hypertension, and hepatitis C virus coinfection. Conclusions. The risk of ESRD remains high among HIV-infected individuals in care but is declining with improvements in virologic suppression. HIV-infected black persons continue to comprise the majority of cases, as a result of higher viral loads, comorbidities, and genetic susceptibility.",
keywords = "Chronic kidney disease (CKD), End-stage renal disease (ESRD), Glomerular filtration rate (GFR), HIV infection/AIDS, HIV/AIDS",
author = "Abraham, {Alison G.} and Althoff, {Keri N.} and Yuezhou Jing and Estrella, {Michelle M.} and Kitahata, {Mari M.} and Wester, {C. William} and Bosch, {Ronald J.} and Heidi Crane and Joseph Eron and Gill, {M. John} and Horberg, {Michael A.} and Justice, {Amy C.} and Marina Klein and Mayor, {Angel M.} and Moore, {Richard D.} and Palella, {Frank J.} and Parikh, {Chirag R.} and Silverberg, {Michael J.} and Golub, {Elizabeth T.} and Jacobson, {Lisa P.} and Sonia Napravnik and Lucas, {Gregory M.} and Kirk, {Gregory D.} and Benson, {Constance A.} and Collier, {Ann C.} and Stephen Boswell and Chris Grasso and Ken Mayer and Hogg, {Robert S.} and Richard Harrigan and Julio Montaner and Angela Cescon and Brooks, {John T.} and Kate Buchacz and Gebo, {Kelly A.} and Benigno Rodriguez and Thorne, {Jennifer E.} and Goedert, {James J.} and Klein, {Marina B.} and Rourke, {Sean B.} and Ann Burchell and Rachlis, {Anita R.} and Hunter-Mellado, {Robert F.} and Deeks, {Steven G.} and Martin, {Jeffrey N.} and Saag, {Michael S.} and Mugavero, {Michael J.} and James Willig and Eron, {Joseph J.} and Crane, {Heidi M.} and Robert Dubrow and David Fiellin and Sterling, {Timothy R.} and David Haas and Kathryn Anastos and Megan Turner and Gange, {Stephen J.} and Kathryn Anastos and McKaig, {Rosemary G.} and Freeman, {Aimee M.} and Carol Lent and {Van Rompaey}, {Stephen E.} and Eric Webster and Liz Morton and Brenda Simon and Hanna, {David B.} and Jinbing Zhang and Jerry Jing and Shari Modur and Hanna, {David B.} and Peter Rebeiro and Cherise Wong and Adell Mendes",
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doi = "10.1093/cid/ciu919",
language = "English (US)",
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pages = "941--949",
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TY - JOUR

T1 - End-stage renal disease among HIV-infected adults in North America

AU - Abraham, Alison G.

AU - Althoff, Keri N.

AU - Jing, Yuezhou

AU - Estrella, Michelle M.

AU - Kitahata, Mari M.

AU - Wester, C. William

AU - Bosch, Ronald J.

AU - Crane, Heidi

AU - Eron, Joseph

AU - Gill, M. John

AU - Horberg, Michael A.

AU - Justice, Amy C.

AU - Klein, Marina

AU - Mayor, Angel M.

AU - Moore, Richard D.

AU - Palella, Frank J.

AU - Parikh, Chirag R.

AU - Silverberg, Michael J.

AU - Golub, Elizabeth T.

AU - Jacobson, Lisa P.

AU - Napravnik, Sonia

AU - Lucas, Gregory M.

AU - Kirk, Gregory D.

AU - Benson, Constance A.

AU - Collier, Ann C.

AU - Boswell, Stephen

AU - Grasso, Chris

AU - Mayer, Ken

AU - Hogg, Robert S.

AU - Harrigan, Richard

AU - Montaner, Julio

AU - Cescon, Angela

AU - Brooks, John T.

AU - Buchacz, Kate

AU - Gebo, Kelly A.

AU - Rodriguez, Benigno

AU - Thorne, Jennifer E.

AU - Goedert, James J.

AU - Klein, Marina B.

AU - Rourke, Sean B.

AU - Burchell, Ann

AU - Rachlis, Anita R.

AU - Hunter-Mellado, Robert F.

AU - Deeks, Steven G.

AU - Martin, Jeffrey N.

AU - Saag, Michael S.

AU - Mugavero, Michael J.

AU - Willig, James

AU - Eron, Joseph J.

AU - Crane, Heidi M.

AU - Dubrow, Robert

AU - Fiellin, David

AU - Sterling, Timothy R.

AU - Haas, David

AU - Anastos, Kathryn

AU - Turner, Megan

AU - Gange, Stephen J.

AU - Anastos, Kathryn

AU - McKaig, Rosemary G.

AU - Freeman, Aimee M.

AU - Lent, Carol

AU - Van Rompaey, Stephen E.

AU - Webster, Eric

AU - Morton, Liz

AU - Simon, Brenda

AU - Hanna, David B.

AU - Zhang, Jinbing

AU - Jing, Jerry

AU - Modur, Shari

AU - Hanna, David B.

AU - Rebeiro, Peter

AU - Wong, Cherise

AU - Mendes, Adell

PY - 2015

Y1 - 2015

N2 - Background. Human immunodeficiency virus (HIV)-infected adults, particularly those of black race, are at high-risk for end-stage renal disease (ESRD), but contributing factors are evolving. We hypothesized that improvements in HIV treatment have led to declines in risk of ESRD, particularly among HIV-infected blacks. Methods. Using data from the North American AIDS Cohort Collaboration for Research and Design from January 2000 to December 2009, we validated 286 incident ESRD cases using abstracted medical evidence of dialysis (lasting >6 months) or renal transplant. A total of 38 354 HIV-infected adults aged 18-80 years contributed 159 825 person-years (PYs). Age- and sex-standardized incidence ratios (SIRs) were estimated by race. Poisson regression was used to identify predictors of ESRD. Results. HIV-infected ESRD cases were more likely to be of black race, have diabetes mellitus or hypertension, inject drugs, and/or have a prior AIDS-defining illness. The overall SIR was 3.2 (95% confidence interval [CI], 2.8- 3.6) but was significantly higher among black patients (4.5 [95% CI, 3.9-5.2]). ESRD incidence declined from 532 to 303 per 100 000 PYs and 138 to 34 per 100 000 PYs over the time period for blacks and nonblacks, respectively, coincident with notable increases in both the prevalence of viral suppression and the prevalence of ESRD risk factors including diabetes mellitus, hypertension, and hepatitis C virus coinfection. Conclusions. The risk of ESRD remains high among HIV-infected individuals in care but is declining with improvements in virologic suppression. HIV-infected black persons continue to comprise the majority of cases, as a result of higher viral loads, comorbidities, and genetic susceptibility.

AB - Background. Human immunodeficiency virus (HIV)-infected adults, particularly those of black race, are at high-risk for end-stage renal disease (ESRD), but contributing factors are evolving. We hypothesized that improvements in HIV treatment have led to declines in risk of ESRD, particularly among HIV-infected blacks. Methods. Using data from the North American AIDS Cohort Collaboration for Research and Design from January 2000 to December 2009, we validated 286 incident ESRD cases using abstracted medical evidence of dialysis (lasting >6 months) or renal transplant. A total of 38 354 HIV-infected adults aged 18-80 years contributed 159 825 person-years (PYs). Age- and sex-standardized incidence ratios (SIRs) were estimated by race. Poisson regression was used to identify predictors of ESRD. Results. HIV-infected ESRD cases were more likely to be of black race, have diabetes mellitus or hypertension, inject drugs, and/or have a prior AIDS-defining illness. The overall SIR was 3.2 (95% confidence interval [CI], 2.8- 3.6) but was significantly higher among black patients (4.5 [95% CI, 3.9-5.2]). ESRD incidence declined from 532 to 303 per 100 000 PYs and 138 to 34 per 100 000 PYs over the time period for blacks and nonblacks, respectively, coincident with notable increases in both the prevalence of viral suppression and the prevalence of ESRD risk factors including diabetes mellitus, hypertension, and hepatitis C virus coinfection. Conclusions. The risk of ESRD remains high among HIV-infected individuals in care but is declining with improvements in virologic suppression. HIV-infected black persons continue to comprise the majority of cases, as a result of higher viral loads, comorbidities, and genetic susceptibility.

KW - Chronic kidney disease (CKD)

KW - End-stage renal disease (ESRD)

KW - Glomerular filtration rate (GFR)

KW - HIV infection/AIDS

KW - HIV/AIDS

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DO - 10.1093/cid/ciu919

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VL - 60

SP - 941

EP - 949

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

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