Emerging themes in IFN-γ-induced macrophage immunity by the p47 and p65 GTPase families

Avinash R. Shenoy, Bae Hoon Kim, Han Pil Choi, Takeshi Matsuzawa, Sangeeta Tiwari, John D. MacMicking

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Vertebrates have evolved complex immune specificity repertoires beyond the primordial components found in lower multi-cellular organisms to combat microbial infections. The type II interferon (IFN-γ) pathway represents one such system, bridging innate and acquired immunity and providing host protection in a cell-autonomous manner. Recent large-scale transcriptome analyses of IFN-γ-dependent gene expression in effector cells such as macrophages have highlighted the prominence of two families of GTPases-p47 IRGs and p65 GBPs-that are now beginning to emerge as major determinants of antimicrobial resistance. Here we discuss the recent clarification of known family members, their cellular biochemistry and host defense functions as a means to understanding the complex innate immune response engendered in higher vertebrates such as humans and mice.

Original languageEnglish (US)
Pages (from-to)771-784
Number of pages14
JournalImmunobiology
Volume212
Issue number9-10
DOIs
StatePublished - Jan 18 2008
Externally publishedYes

Fingerprint

GTP Phosphohydrolases
Innate Immunity
Interferons
Vertebrates
Immunity
Macrophages
Gene Expression Profiling
Adaptive Immunity
Antigen-Antibody Complex
Biochemistry
Interferon-gamma
Gene Expression
Infection

Keywords

  • Autophagy
  • GBP
  • GTPase
  • IFN-γ
  • Macrophage
  • p47 IRG
  • Phagosome

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Hematology

Cite this

Shenoy, A. R., Kim, B. H., Choi, H. P., Matsuzawa, T., Tiwari, S., & MacMicking, J. D. (2008). Emerging themes in IFN-γ-induced macrophage immunity by the p47 and p65 GTPase families. Immunobiology, 212(9-10), 771-784. https://doi.org/10.1016/j.imbio.2007.09.018

Emerging themes in IFN-γ-induced macrophage immunity by the p47 and p65 GTPase families. / Shenoy, Avinash R.; Kim, Bae Hoon; Choi, Han Pil; Matsuzawa, Takeshi; Tiwari, Sangeeta; MacMicking, John D.

In: Immunobiology, Vol. 212, No. 9-10, 18.01.2008, p. 771-784.

Research output: Contribution to journalArticle

Shenoy, AR, Kim, BH, Choi, HP, Matsuzawa, T, Tiwari, S & MacMicking, JD 2008, 'Emerging themes in IFN-γ-induced macrophage immunity by the p47 and p65 GTPase families', Immunobiology, vol. 212, no. 9-10, pp. 771-784. https://doi.org/10.1016/j.imbio.2007.09.018
Shenoy, Avinash R. ; Kim, Bae Hoon ; Choi, Han Pil ; Matsuzawa, Takeshi ; Tiwari, Sangeeta ; MacMicking, John D. / Emerging themes in IFN-γ-induced macrophage immunity by the p47 and p65 GTPase families. In: Immunobiology. 2008 ; Vol. 212, No. 9-10. pp. 771-784.
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