Emerging themes in IFN-γ-induced macrophage immunity by the p47 and p65 GTPase families

Avinash R. Shenoy, Bae Hoon Kim, Han Pil Choi, Takeshi Matsuzawa, Sangeeta Tiwari, John D. MacMicking

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Vertebrates have evolved complex immune specificity repertoires beyond the primordial components found in lower multi-cellular organisms to combat microbial infections. The type II interferon (IFN-γ) pathway represents one such system, bridging innate and acquired immunity and providing host protection in a cell-autonomous manner. Recent large-scale transcriptome analyses of IFN-γ-dependent gene expression in effector cells such as macrophages have highlighted the prominence of two families of GTPases-p47 IRGs and p65 GBPs-that are now beginning to emerge as major determinants of antimicrobial resistance. Here we discuss the recent clarification of known family members, their cellular biochemistry and host defense functions as a means to understanding the complex innate immune response engendered in higher vertebrates such as humans and mice.

Original languageEnglish (US)
Pages (from-to)771-784
Number of pages14
JournalImmunobiology
Volume212
Issue number9-10
DOIs
Publication statusPublished - Jan 18 2008

    Fingerprint

Keywords

  • Autophagy
  • GBP
  • GTPase
  • IFN-γ
  • Macrophage
  • Phagosome
  • p47 IRG

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Hematology

Cite this

Shenoy, A. R., Kim, B. H., Choi, H. P., Matsuzawa, T., Tiwari, S., & MacMicking, J. D. (2008). Emerging themes in IFN-γ-induced macrophage immunity by the p47 and p65 GTPase families. Immunobiology, 212(9-10), 771-784. https://doi.org/10.1016/j.imbio.2007.09.018