Emerging roles for macrophages in cardiac injury: Cytoprotection, repair, and regeneration

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The mammalian heart contains a population of resident macrophages that expands in response to myocardial infarction through the recruitment of monocytes. Infarct macrophages exhibit high phenotypic diversity and respond to microenvironmental cues by altering their functional properties and secretory profile. In this issue of the JCI, de Couto and colleagues demonstrate that infiltrating macrophages can be primed to acquire a cardioprotective phenotype in ischemic heart and exert this proactive effect through activation of an antiapoptotic program in cardiomyocytes. This study supports the growing body of evidence that suggests that macrophage subpopulations can be modulated to mediate cytoprotective, reparative, and even regenerative functions in the infarcted heart. The cellular mechanisms and molecular signals driving these macrophage phenotypes are yet unknown; however, harnessing the remarkable potential of the macrophage in regulating cell survival and tissue regeneration may hold therapeutic promise for myocardial infarction.

Original languageEnglish (US)
Pages (from-to)2927-2930
Number of pages4
JournalJournal of Clinical Investigation
Volume125
Issue number8
DOIs
StatePublished - Aug 3 2015

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Cytoprotection
Regeneration
Macrophages
Wounds and Injuries
Myocardial Infarction
Phenotype
Cardiac Myocytes
Cues
Monocytes
Cell Survival
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Emerging roles for macrophages in cardiac injury : Cytoprotection, repair, and regeneration. / Frangogiannis, Nikolaos G.

In: Journal of Clinical Investigation, Vol. 125, No. 8, 03.08.2015, p. 2927-2930.

Research output: Contribution to journalArticle

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