TY - JOUR
T1 - Emerging mechanisms of cell competition
AU - Baker, Nicholas E.
N1 - Funding Information:
The author thanks H. Buelow, S. Emmons, C. Khan, M. Kiparaki and the reviewers for comments on the manuscript and C.-H. Lee for Figure 1b. Research into cell competition mechanisms in the author’s laboratory is supported by NIH grants GM104213 and GM120451 and the Albert Einstein College Human Genetics Program.
PY - 2020/11/1
Y1 - 2020/11/1
N2 - The growth and survival of cells within tissues can be affected by ‘cell competition’ between different cell clones. This phenomenon was initially recognized between wild-type cells and cells with mutations in ribosomal protein (Rp) genes in Drosophila melanogaster. However, competition also affects D. melanogaster cells with mutations in epithelial polarity genes, and wild-type cells exposed to ‘super-competitor’ cells with mutation in the Salvador–Warts–Hippo tumour suppressor pathway or expressing elevated levels of Myc. More recently, cell competition and super-competition were recognized in mammalian development, organ homeostasis and cancer. Genetic and cell biological studies have revealed that mechanisms underlying cell competition include the molecular recognition of ‘different’ cells, signalling imbalances between distinct cell populations and the mechanical consequences of differential growth rates; these mechanisms may also involve innate immune proteins, p53 and changes in translation.
AB - The growth and survival of cells within tissues can be affected by ‘cell competition’ between different cell clones. This phenomenon was initially recognized between wild-type cells and cells with mutations in ribosomal protein (Rp) genes in Drosophila melanogaster. However, competition also affects D. melanogaster cells with mutations in epithelial polarity genes, and wild-type cells exposed to ‘super-competitor’ cells with mutation in the Salvador–Warts–Hippo tumour suppressor pathway or expressing elevated levels of Myc. More recently, cell competition and super-competition were recognized in mammalian development, organ homeostasis and cancer. Genetic and cell biological studies have revealed that mechanisms underlying cell competition include the molecular recognition of ‘different’ cells, signalling imbalances between distinct cell populations and the mechanical consequences of differential growth rates; these mechanisms may also involve innate immune proteins, p53 and changes in translation.
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U2 - 10.1038/s41576-020-0262-8
DO - 10.1038/s41576-020-0262-8
M3 - Review article
C2 - 32778819
AN - SCOPUS:85089186848
VL - 21
SP - 683
EP - 697
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
SN - 1471-0056
IS - 11
ER -